LOC100506314 interacted with STAT3 and MIF and inhibited IL-6 and IL-17 expression by suppressing the STAT3, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-魏B), AKT, and ERK pathways. Enhanced expression of LOC100506314 in T cells may be a potential...
tumor-derived TNF-α efficiently induces programmed death-ligand 1 (PD-L1) expression on mast cells by activating nuclear factor kappa-light-chain-enhancer of
Nuclear factor kappa-light-chain-enhancer of activated B cells PCA: Principal component analysis PCs: Principal components RA: Rheumatoid arthritis RF: Rheumatoid factor SWAN: Subset-quantile within array normalisation T1D: Type 1 diabetes UTR: Untranslated region ...
Secondary antibodies used were (H + L)-horse radish peroxidase (HRP) conjugate (BioRad) or kappa light chain HRP conjugate (Abcam). ImageJ software (http://imagej.nih.gov/ij, National Institute of Health) was used for densitometric analysis of protein bands. Behaviour. Forepaw ...
All synthetic peptides, goat anti human immunoglobulin kappa light chain (hIgk-LC) antibody, recombinant Protein-L and the other chemicals were purchased from Sigma-Aldrich. The MGC cDNA clone of human pancreatic RNase1 was purchased from Thermo Fisher Scientific Inc. The PaCa cell line Capan-1...
Results Subjects with DD, PU, RA and AIDS have significantly higher free kappa, lambda and total urinary light chain excretion than NC (p 0.01). Subjects with established MS and CIS had higher excretion of free kappa, lambda and total urinary light chain excretion than NC (p=0.05). Urinary...
Nuclear factor kappa-light-chain-enhancer of activated B cells NSAID: Non-steroid anti-inflammatory drug PGC: peroxisome proliferator - activated receptor gamma coactivator PKC: Protein kinase C PMA: Phorbol myristate acetate RANTES: Regulated on activation, normal T cell expressed and secreted ...
In a second group of mice, we also measured the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) p65 because cytokines secreted by senescent cells can activate NFκB in surrounding cells, leading to a wave of increased production of pro-inflammatory cytokines...
Subjects with established MS and CIS had higher excretion of free kappa, lambda and total urinary light chain excretion than NC (p=0.05). Urinary FLC excretion did not correlate with gadolinium-enhancing lesions on MRI. CONCLUSIONS: Increased urinary FLC are a biomarker of plasma cell and B ...
light chain leading to a skewed ratio between the two light chains, as well as overall increased levels.10An abnormal serum free light ratio becomes more common along the spectrum of disease progression from MGUS to SMM and finally to active MM.11A polyclonal elevation of both kappa and lambda...