Analysis of serum free light chains (FLCs) showed increased levels of kappa FLC, resulting in an abnormally elevated kappa/lambda FLC ratio. No Bence鈥揓ones proteinuria was present. Bone marrow aspiration showed 6% plasma cells, and no sign of myeloma-associated end-organ damage was evident. ...
Despite these in vitro findings, β-TrCP1 is paradoxically upregulated in 56% of the CRC as compared with normal tissue, and its overexpression was correlated with reduced apoptosis and worse prognosis.78 Elevated activity of β-TRCP has been widely detected in CRC cells, and it has been ...
RESULTS. The overall diagnostic sensitivity of the Optilite Freelite assays was 59.4%, calculated as the frequency of abnormal free light chain ratio (rFLC) in intact immunoglobulin MGUS, and abnormal rFLC with concurrent elevated involved FLC level in LC-MGUS. The diagnostic sensitivity was: ...
Clinical data, kappa free light chains, and oligoclonal band status were compared at the time of initial diagnosis and after follow-up to identify converters from clinically isolated syndrome to multiple sclerosis. An elevated kappa free light chain index (>5.9) was found in 79/83 patients (95...
Clinical data, kappa free light chains, and oligoclonal band status were compared at the time of initial diagnosis and after follow-up to identify converters from clinically isolated syndrome to multiple sclerosis. An elevated kappa free light chain index (>5.9) was found in 79/83 patients (95...
1.4. Immune Paresis and MGUS Identified risk factors for disease evolution, from MGUS to MM, comprise the amount and type of M-protein, and the ratio of free light immunoglobulin chains. However, several researchers have demonstrated that the suppression of polyclonal immunoglobulin (PIg) ...