Numerous studies have demonstrated elevated kappa free light chains (KFLCs) in CSF of multiple sclerosis (MS) patients. However, so far only small cohorts have been examined, and generally only through qualitative KFLCs analysis. Using a recently developed free light chain (FLC) immunoassay, it ...
Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis. J Neurol 2008;255:1508- 14.Presslauer S, Milosavljevic D, Brucke T, Bayer P, Hubl W (2008) Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis. J ...
Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory ...
Kappa free light chains (KFLC) index has been described as a reliable marker of intrathecal immunoglobulin G (IgG) synthesis in multiple sclerosis (MS), resulting even more accurate than IgG index to discriminate MS from other neurological diseases1,2,3. Immunoglobulin free light chains (FLC), ...
Since OCB tests are based on non-quantitative and difficult to standardise techniques, measurement of immunoglobulin kappa free light chains (KFLC) may represent an easier to use quantitative test. Methods KFLC were measured in CSF and serum of 211 patients using ELISA. These include patients ...
Validation of kappa free light chains as a diagnostic biomarker in multiple sclerosis and clinically isolated syndrome: A multicenter study 2016, Multiple Sclerosis Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis 2008, Journal of Neurology Immunoglobulin-free...
Elevated IgG distributed in oligoclonal bands is characteristically observed in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) or subacute sclerosing panencephalitis (SSPE). Similarly, IgG in bands has been detect... DH Mattson,RP Roos,BGW Arnason - 《Nature》 被引量: 21...
light chain ratios have been defined by flow cytometry29,30but quantitative analysis is difficult to apply to histologic sections. The goal is identification of light chain restriction, or monotypia, in which one of the light chains is present on an abnormally large proportion of cells. Monotyp...
Introduction Kappa and lambda free light chains (FLC) are a side product of immunoglobulin synthesis. They are small molecular weight proteins and are present in serum of healthy people. They are increased in various diseases with enhanced immunoglobulin production. Like other small molecular we...
The unidentified positive validation group was classified according to heavy chain types—IgG positive (IgG+), IgA positive (IgA+), IgM positive (IgM+), and others (IgG-, IgA-, and IgM-negative)—and the proportions of these types bound to different light chains were calculated. The ...