Light-chain nephropathy Light chain deposition disease (LCDD) is characterized by the tissue deposition of monotypic immunoglobulin light chains of either kappa or lambda isotype... LST Fang - 《Kidney International》 被引量: 140发表: 1985年 Free kappa and lambda light chain levels in the cerebros...
Free light chainsKidney diseaseInflammatory diseaseKappa (kappa) or lambda (lambda) free light chains (FLCs) are produced from B cells during immunoglobulin synthesis. FLCs have been shown to participate in several key processes of immune responses. They are necessary to adjust PMN functions and ...
Free kappa and lambda light chains were assayed by particle-counting immunoassay in cerebrospinal fluid (CSF) from patients with various neurological disorders. Detection limits were 25 and 50 ng/ml, respectively. Values of free kappa chain were higher than 50 ng/ml (upper reference limit) in 15...
The variability subgroup of human monoclonal kappa chains purified from urine in 3 consecutive patients with myeloma associated light chain deposition disease was determined from amino acid sequences of their first framework regions (FR1). N-glycosylation was searched for by N-glycosidase F treatment....
FLC kappa: up to 23,000 mg/L FLC lambda: up to 57,000 mg/L Webinars Serum free light chains testing in monoclonal gammopathies Learn about the clinical and laboratory aspects impacting serum free light chains testing in diagnosis and monitoring of monoclonal gammopathies. Watch now Excludin...
mentioned in their paper that lambda light chains are frequently responsible for triggering the activation of inflammatory factors in autoimmune disorders, and an increase in their levels will cause various pathological changes in serum [26]. Because the Beckman IMMAGE800 immune-scattering turbidity ...
for a total of 135 days (e–h). There was no apparent change in serum λFLC concentration throughout the study and the changes in serum FLC ratios (κ:λ) were consistent with the fluctuations in serum κFLC concentrations. κFLC, kappa free light chain; λFLC, lambda free light chain...
Kappa and lambda light chain disease: survival rates and clinical manifestations A 1:1 ratio of males to females was similar to the ratios in IgA and IgG myeloma, but differed from the 3:1 ratio reported for IgD myeloma. Plasma-cell leukemia developed in 7/97 LCD patients, an incidence th...