However, when he did not improve and continued requiring dialysis, further workup showed elevated serum kappa free light chains and urine Bence-Jones protein. Renal biopsy showed kappa light chain crystalline tubulopathy, interstitial inflammation, and extensive fibrosis. Subsequent bone marrow biopsy ...
Light-chain nephropathy Light chain deposition disease (LCDD) is characterized by the tissue deposition of monotypic immunoglobulin light chains of either kappa or lambda isotype... LST Fang - 《Kidney International》 被引量: 140发表: 1985年 Free kappa and lambda light chain levels in the cerebros...
In MS, high levels of free kappa and lambda indices correlated significantly (P < 0.01) with either the presence of oligoclonal bands or a high IgG index. Local synthesis of free light chains is an additional marker of an ongoing immune response within the CNS, especially in MS....
BMC Nephrol. 2020;21:111 Available from: : https://doi.org/10.1186/s12882-020-01771-3 8 Long TE, et al. Defining new reference intervals for serum free light chains in individuals with chronic kidney disease: Results of the iStopMM study. Blood Cancer J. 2022 Sep 14;12(9):133. ...
Changes in free light chains may affect the ratio of total serum light chains. The serum free light chain ratio is often outside of the normal reference range in several conditions, including chronic infection (osteomyelitis, endocarditis, HIV, EBV), inflammation, IgG4-related disease, autoimmune...
The variability subgroup of human monoclonal kappa chains purified from urine in 3 consecutive patients with myeloma associated light chain deposition disease was determined from amino acid sequences of their first framework regions (FR1). N-glycosylation was searched for by N-glycosidase F treatment....
multiple myeloma (MM), incurability remains an ongoing clinical challenge1. MM is characterised by the expansion of malignant monoclonal plasma cells (PCs) within the bone marrow (BM), and production of excess monoclonal immunoglobulin (M protein) and/or isotype-restricted free light chains (FLC)...
Free light chainsKidney diseaseInflammatory diseaseKappa (kappa) or lambda (lambda) free light chains (FLCs) are produced from B cells during immunoglobulin synthesis. FLCs have been shown to participate in several key processes of immune responses. They are necessary to adjust PMN functions and ...
Renal ultrasonography revealed normal kidney dimensions, with a slight decrease in the normal parenchyma-sinus differentiation. The complementary study identified free kappa light chains in urine (73,9 mg/dL) and bone marrow study fulfilled the criteria for multiple myeloma. Search for amyloid fibrils...
Patient's parameters and generation of the rat model (rR) were described in the supplemental methods and Supplemental Figure 1. Human jLC was expressed in most B and plasma cells (PC) together with rat heavy chains (HC) (Supplemental Figure 1C). The human jLC was readily detected in serum...