Kappa and lambda light chain disease: survival rates and clinical manifestations. Blood. 1976;48:41-51.Shustik C, Bergsagel DE, Pruzanski W. Kappa and lambda light chain disease: survival rates and clinical manifestations. Blood 1976; 48: 41-51....
κ(Kappa-LightChain)和λ(Lambda-LightChain)两兄弟 κ和λ是免疫球蛋白上的两条肽链。每个免疫球蛋白分子有两条相同的重链和两条相同的轻链。两条相同的轻链即为κ和λ ,可标记带有轻链的B淋巴细胞、浆细胞和免疫母细胞。 正常情况下轻链和重链的分泌是平衡的,二者可结合成完整的免疫球蛋白分子。淋巴细胞在发...
参考文献: 1.MoghimiM, KashkooliBehrooziM,MaghbooliM,etal.Assoaition between abnormal serum free light chain sratioand known prognostic factorsin lyphoma;anephrologyview point[J].JRenal InjPrev,2016. 2.Jardin F, Delfau-Larue MH, Molina TJ,etal. Immunoglobulin heavy chain/ light chain pairmeasu...
Free Light Chains (FLCs) are immunoglobulin light chains which are circulating in serum in a free state (unbound). There are two types of immunoglobulin light chain produced in humans, designated kappa (κ) and lambda (λ). The quantification of serum FLC is used as an aid in the diagnosi...
1.MoghimiM, KashkooliBehrooziM,MaghbooliM,etal.Assoaition between abnormal serum free light chain sratioand known prognostic factorsin lyphoma;anephrologyview point[J].JRenal InjPrev,2016. 2.Jardin F, Delfau-Larue MH, Molina TJ,etal. Immunoglobulin heavy chain/ light chain pairmeasurement is ...
Free kappa and lambda light chains were assayed by particle-counting immunoassay in cerebrospinal fluid (CSF) from patients with various neurological disorders. Detection limits were 25 and 50 ng/ml, respectively. Values of free kappa chain were higher than 50 ng/ml (upper reference limit) in 15...
Light chain deposition disease (LCDD) is characterized by the tissue deposition of monotypic immunoglobulin light chains of either kappa or lambda isotype... LST Fang - 《Kidney International》 被引量: 140发表: 1985年 Free kappa and lambda light chain levels in the cerebrospinal fluid of patients...
Results: The detection limit of this method on the Hitachi-Analyzer 917 is 3.7 mg/l for kappa-FLC and 7.0 mg/1 for lambda-FLC, respectively. In our patients of different disease stages and states, the correlation of the results of the Freelite assay and the results of the detection of ...
Comparison of serum and urine kappa/lambda ratios as a kappa/lambda index may help reduce the need for more complex immunoelectrophoresis techniques in identifying free light chains in urine. 展开 关键词: IMMUNOFIXATION ELECTROPHORESIS LIGHTCHAIN DEPOSITION DISEASE SENSITIVITY URINE ...
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