Borderline high serum free light chain k/ ratios are seen not only in dialysis patients but also in non-dialysis-dependent renal impairment and inflammatory states. Am J Clin Pathol 2009; 132: 309.Marshall G, Tate J, Mollee P. Borderline high serum free light chain kappa/lambda ratios are...
In addition, dialysis dependence had no impact on OS or event-free survival. Historically, long-term renal recovery after HDM/SCT is not possible for patients with AL amyloidosis or MIDD; however, this treatment is very successful in bridging patients to renal transplantation (33% at a median ...
Human Ang-2 antigen was administered directly, with an adjuvant to stimulate the immune response, to a VELOCIMMUNE® mouse comprising DNA encoding human Immunoglobulin heavy and kappa light chain variable regions. The antibody immune response was monitored by an Ang-2-specific immunoassay. When a...
When we say "Kappa as we know it", we mean Kappa in its legend of sportswear propensity. With one of the most memorable logos ever — need "Omini" — Kappa made a splash in the 1984 Los Angeles Olympics with the first tracksuit featuring a side-vertical logo stripe. A simple idea ...
Monoclonal immunoglobulin deposition disease (MIDD) is a rare complication of plasma cell disorders, defined by linear Congo red-negative deposits of monoclonal light chain, heavy chain, or both along basement membranes. While renal involvement is prominent, treatment strategies, such as the impact of...
Elevated free fatty acids and cytokines can activate the inhibitory kappa B kinase (IKK) complex and NF-κB both through activating Toll-like receptors and through inducing cellular stresses (oxidative or/and endoplasmic reticulum) [29]. High fructose consumption can activate NF-κB via sphingosine ...
In general, that response involves the following steps: first, toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) to initiate the antiviral innate immune response [152,153]; next, the nuclear factor kappa light chain enhancer of activated B cells (NF-κB) and ...
Kappaun, R.; Meira, A.D.D.; Walber, M. Parameters for modeling passive suspensions of spray bars. Eng. Agric. 2021, 41, 368–378. [Google Scholar] [CrossRef] Cui, L.f.; Xue, X.Y.; Le, F.X. Adaptive robust precision control of an active spray boom suspension with disturbance ...
Our study, for the first time, used colon organoids from subjects with HBP to show that butyrate treatment rescued altered expression of genes associated with immune modulation, such as the suppression of nuclear factor kappa B activation and the inhibition of histone deacetylase. For example, CEAC...
Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J. Biol. Chem. 2001, 276, 32008–32015. [Google Scholar] [CrossRef] Singh, S.; Nagalakshmi, D.; Sharma, K.K.; Ravichandiran, V. Natural antioxidants for neuroinflammatory disorders and ...