A unique case of kappa light-chain disease associated with cryoglobulinemia, pyroglobulinemia, and hyperviscosity syndrome. Am J Med 1989;86:596-602BACHRACH H, MYERS J, BARTHOLOMEW W. A unique case of kappa light-chain disease associated with cryo- globulinemia, pyroglobulinemia and hyper...
Light chain deposition disease (LCDD) is characterized by the tissue deposition of monotypic immunoglobulin light chains of either kappa or lambda isotype... LST Fang - 《Kidney International》 被引量: 140发表: 1985年 Free kappa and lambda light chain levels in the cerebrospinal fluid of patients...
The most characteristic histologic lesion of light chain deposition disease (LCDD) is nodular glomerulosclerosis, which must be distinguished from diabetic glomerulosclerosis by using electron microscopy. [1] See the image below. Light chain–associated renal disorders. Light microscopy (hematoxylin and eos...
We describe a 39-year-old man who developed kappa light chain nodular glomerulosclerosis with superimposed conspicuous crescent formation and extensive tubulointerstitial injury. The clinical picture was characterized by nephrotic syndrome and rapidly progressive glomerulonephritis. Incessantly progressive loss of...
The level of serum kappa light chain was 270 mg/L and that of lambda chain was 34 mg/L. Urinalysis demonstrated proteinuria of only 0.1 g/day without hematuria, but urinary 尾2-microglobulin was abnormally high at 19 500 渭g/L (normal range, <230). Renal biopsy revealed strongly ...
Free Kappa light chain in a sample of Egyptian multiple sclerosis patients (a pilot study) Multiple sclerosis is a chronic autoimmune-mediated demyelinating disease of the central nervous system that is usually associated with varying degrees of ... AEA Shehab,SI Bakr,RM Saleh,... - 《Egyptian...
Numerous studies have demonstrated elevated kappa free light chains (KFLCs) in CSF of multiple sclerosis (MS) patients. However, so far only small cohorts have been examined, and generally only through qualitative KFLCs analysis. Using a recently developed free light chain (FLC) immunoassay, it ...
Comparison of serum and urine kappa/lambda ratios as a kappa/lambda index may help reduce the need for more complex immunoelectrophoresis techniques in identifying free light chains in urine. 展开 关键词: IMMUNOFIXATION ELECTROPHORESIS LIGHTCHAIN DEPOSITION DISEASE SENSITIVITY URINE ...
Kappa light chain nephropathy was characterized by predominant linear tubular basement membrane κ deposits, and nodular mesangial and linear glomerular basement membrane κ immunostaining. Lambda light chain nephropathy was characterized by linear λ glomerular basement membrane and tubular basement membrane ...
Cerebrospinal fluid (CSF) kappa free light chain (KFLC) index has been described as a reliable marker of intrathecal IgG synthesis to diagnose multiple sclerosis (MS). Our aims were: (1) to compare the efficiency of KFLC through different interpretation