Additionally, STUB1 mediates K63 linked ubiquitination of HIF1A. Our findings add a new regulatory step and increase the specificity of the molecular mechanism involved in CMA degradation of HIF1A, expanding the role of ubiquitination to yet another biological process, since the same mechanism might...
K63-linked ubiquitination has been linked to a number of functions including signal transduction, protein trafficking, protein–protein interaction, and DNA damage response. TRAF2-mediated K63-linked ubiquitination has been to shown to function in protein–protein interaction and enzymatic activity [20,...
Ubiquitinationisapost-translationalmodificationthatsignalsmultipleprocesses,including proteindegradation,trafficking,andDNArepair.Polyubiquitinaccumulatesgloballyduringthe oxidativestressresponse,whichhasbeenmainlyattributedtoincreasedubiquitinconjugationand perturbationsinproteindegradation.HereweshowthattheunconventionalK63-linked ...
HTLV-1 tax protein regulates MCL-1 stability through TRAF6-mediated K63-linked ubiquitination to promote cell survival [63]. SKP2 knockdown inhibits EZH2 expression prostate cancer cells by promoting TRAF6-induced K63-linked ubiquitination of EZH2 for degradation [64]. Epigallocatechin-3-gallate has ...
mechanism to target proteins for degradation and as a result, ubiquitin was originally named ATP-dependent Proteolysis Factor 1 (APF-1). In addition to protein degradation, ubiquitination has been shown to mediate a variety of biological processes such as signal transduction, endocytosis, and post-...
Plays an important role in the ubiquitin-proteasome pathway. Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquiti...
Targeted disruption of parkin gene expression in mice causes a significant decrease in UCH-L1 ubiquitination with a concomitant increase in UCH-L1 protein level in brain, supporting an in vivo role of parkin in regulating UCH-L1 ubiquitination and degradation. Our findings reveal a direct link ...
Plays an important role in the ubiquitin-proteasome pathway. Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquiti...
ubiquitination mitochondrion transport along microtubule neuron projection morphogenesis regulation of mitochondrial membrane potential regulation of proteasomal protein catabolic process regulation of neuron death positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of ...
However, the initial processes for detecting stalled translation that result in degradation remain to be determined. Among the factors identified to date, two E3 ubiquitin ligases have been reported to function in distinct manners. Because ubiquitination is one of the most versatile of cellular ...