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Synthetic peptide within Human K63-linkage Specific Ubiquitin.AA range:36-85. Specificity: Ubiquitin (linkage-specific K63)MonoclonalAntibody detects endogenous levels ofUbiquitin (linkage-specific K63)protein. Product images Fig : Western blot analysis of Ubiquitin(linkage-specific K63) on different ...
The UIMs appear to gate or orient specific linkages for cleavage by the Josephin domain, since UIM mutations eliminate ataxin-3's K63-linkage specificity. Our results establish ataxin-3 as the first reported, mixed linkage ubiquitin-editing enzyme. Funding: R01 NS038712 (HLP)...
Transforming Growth Factor Β-activated Kinase (TAK1)Poly-ubiquitin (poly-Ub) is involved in various cellular processes through the linkage-specific recognition of Ub-binding domains (UBD). In this study, using molecular dynamics (MD) simulation together with an enhanced sampling method, we ...