阿司匹林通过 K63 泛素化抑制蛋白酶体降解并促进 α- 突触核蛋白聚集体清除:开启帕金森病治疗新视野 《Nature Communications》:Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination 编辑推荐: 阿司匹林(Aspirin)作为常用药物,其对赖氨酸泛素化及蛋白降解的影响...
图3 PDI被多聚核糖基化及K63 泛素化修饰影响PR1蛋白的折叠及运输 综上所述,为了响应 PAMP 或病原体,PARP 蛋白通过物理相互作用和 PARylation 招募 UBC13 和 PDI,这反过来促进 UBC13 介导的 PDI 的 K63 Ubiquitination以激活 PDI。随后,PDI 与其他分泌蛋白协同工作以确保蛋白质的正确折叠和分泌到胞外空间. 该...
Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent evidence has shown that the control of multiple immune functions, including chronic inflammation, pathogen responses, lymphocyte activation, and regulatory signaling, is altered by K63 ubiquitination. In this review...
k63位泛素化(K63-linked ubiquitination)是一种特殊类型的泛素化修饰过程,它通过将一条或多条含有29号赖氨酸(Lysine 63,K63)残基的泛素蛋白共价连接到靶蛋白上来进行调控。与其他类型的泛素化修饰相比,k63位泛素化具有独特的生物学特征和功能。 2.2 作用机制: k63位泛素化主要通过E1激活酶、E2结合酶和E3连接酶...
英文名字 K63-linked Di-Ubiquitin 供应商 Biovision 产品货号 6418-50 产品报价 ￥已停产 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868. 产品新闻 背景资料 Poly-ubiquitination of target proteins through K63 has recently become the focus...
Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquitin is first activated by forming a thiolester complex with ...
2025年1月9日,中山大学孙逸仙纪念医院廖建友、尹东、郑亿庆共同通讯在Nature communications上在线发表题为“DCAF13-mediated K63-linked ubiquitination of RNA polymerase I promotes uncontrolled proliferation in Breast Cancer”的研究论文...
Ubiquitination of MBNL1 Is Required for Its Cytoplasmic Localization and Function in Promoting Neurite Outgrowth.【Cell Reports】点击下载 《IP》 Mass spectrometry analysis of K63-ubiquitinated targets in response to oxidative stress.【Data in brief】点击下载 ...
K63-linked Tetra-Ubiquitin 供应商 Biovision 产品货号 6420-25 产品报价 ￥已停产 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868. 产品新闻 背景资料 Poly-ubiquitination of target proteins through K63 has recently become the focus of in...
as an interaction partner of DYRK1A. Our data suggest that TRAF2 binds to PVQE motif residing in between the PEST and histidine repeat domain (HRD) of DYRK1A protein, and mediates K63-linked ubiquitination of DYRK1A. This results in translocation of DYRK1A to the vesicle membrane. DYRK1A ...