Our studies have also shown for the first time that E2F1 can be modified by K11-linkage specific ubiquitin chain formation (Ub-K11). The formation of Ub-K11 chains on E2F1 is increased in the presence of Cdh1 and accumulated in the presence of proteasome inhibitor, suggesting that APC/CCdh1...
Our studies have also shown for the first time that E2F1 can be modified by K11-linkage specific ubiquitin chain formation (Ub-K11). The formation of Ub-K11 chains on E2F1 is increased in the presence of Cdh1 and accumulated in the presence of proteasome inhibitor, suggesting that APC/C...
摘要: K11-linked diubiquitin adopts a conformation distinct from other diubiquitins A K11-linked polyubiquitin-specific antibody was engineered UbcH10/Ube2S and APC/C are the major source of mitotic K11-linked chains invivo K11-linked chains act as proteasomal degradation signals invivo关键词:...
Our study, therefore, revealed, for the first time, that there is a negative cross-talk between CRL1 and CRL5 through SAG-mediated ubiquitylation and degradation of β-TrCP1, and that CRL5 E3 can mediate K11-linked ubiquitin chain through SAG binding to specific E2s. Results A cross-talk ...