Hu X., Chen J., Wang L., Ivashkiv L.B.: Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation. J. Leukoc. Biol., 2007; 82: 237-243Ivashkiv LB. Crosstalk with the Jak-STAT pathway in inflammation. In: Jak- Stat signaling: from basics ...
1、抑制JAK-STAT通路可纠正干燥病中的唾液腺炎症和干扰素驱动的免疫激活 Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren's disease Ann Rheum Dis; IF: 27.400; DOI: 10.1136/ard-2023-224842 内容概要: ① 干燥病(SjD)是第二常见的系...
Several of the pro-inflammatory IL-family cytokines, including most prominently, IL-6, IL-12, IL-17, IL-23, as well as IFN-, activate the Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) signaling pathway where phosphorylated (i.e. activated) STAT proteins become ...
篇名: 中药干预JAK/STAT信号通路防治脓毒症的研究进展 TITLE: Research progress on the prevention and treatment of sepsis by intervening in JAK/STAT signaling pathway with traditional Chinese medicine 摘要: 脓毒症是一种由感染引发的危及生命的器官功能障碍,Janus激酶/信号转导和转录激活因子(JAK/STAT)信号...
Hemophagocyticlymphohistiocytosis;Pathogenesis; JAK-STAT pathway; Ruxolitinib; Treatment 噬血细胞性淋巴组织细胞增生症(HLH)主要是由于自然杀伤(naturalkiller,NK)细胞及细胞毒性T(cytotoxicT cell,CTL)细胞的杀伤功能缺陷,导致淋巴细胞增殖、活化,产生并释放大量细胞因子(如白...
JAK/ STAT pathway and inflammation Macrophages differentiate into diverse phenotypes, including pro-inflammatory M1 and anti-inflammatory M2, owing to the encompassing microenvironment. M1/M2 balance is essential for maintaining the functionality of the immune system. In vivo and in vitro studies have ...
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus sig
Traditional Chinese medicine compounds (such as Zuojinfang) and traditional Chinese medicine injections (such as Astragalus injection, Xuebijing injection) can also inhibit inflammation, protect organ function, and reduce sepsis-related damage by regulating JAK/STAT signaling pathway. Although traditional ...
Deoxynivalenol (DON) and T-2 toxin commonly affect cells of the immune system and cause inflammation and apoptosis. Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is highly associated with inflammatory process and apoptosis and is worth investigating its role when ...
如下所示,JAK/信号转导和转录激活子(STAT)是重要的胞内途径,许多不同的细胞外可溶性分子通过达到膜受体,向细胞核发出信号。JAK信号通路的异常激活已经在许多免疫介导的疾病中被观察到,包括类风湿关节炎(RA)、系统性红斑狼疮、银屑病关...