Rybinski, M. (2012) Model-based selection of the robust JAK-STAT activation mechanism. J Theoretical Bio 309: 34-46. O’Shea, J.J., et al.(2004) A new modality for immunosuppression: targeting the JAK/STAT pathway.Nat Rev Drug Discovery 3: 555-564. ...
其中JAK1、JAK2和TYK2在人体各组织细胞中均有表达,JAK3主要表达于各造血组织细胞。 作为JAK-STAT信号通路的核心,JAK家族激酶参与了细胞增殖、分化、凋亡以及免疫调节等多种重要的生物学过程。因此,只要抑制JAK激酶,就可以阻碍相关肿瘤、血液系统疾病、类风湿性关节炎等...
1. Ananthakrishnan R, Hallam K, LiQ,Ramasamy R. JAK-STAT pathway in cardiac ischemic stress. Vascul Pharmacol.2005Oct 28; PubMed ID: 16260187 2. Walker JG, SMith MD. The Jak-STAT pathwayin rheumatoid arthritis. J. Rheumatol. 2005 Sep;32(9):1650-3. PubMedID:16142855 3. Marrero MB. ...
The JAK/STAT pathway, through the signal cascade activation mediated by the interaction with many cytokines, acts on bone cells and appears to be involved in bone remodeling process. However, many other studies are needed to completely understand the molecular mechanism underlying these bone process....
STAT单体停靠必要位点。酪氨酸磷酸化的STAT 蛋白作为主要的触发事件,导致STAT二聚体化、核 易位、结合DNA、诱导靶基因表达等一系列反应。 然而,磷酸化的酪氨酸也可以通过非依赖的JAK/ STAT通路进行信号传递,即并不是所有的细胞活动 都需要JAK的活性(即非磷酸化状态的STATs),翻 ...
Keywords:JAK/STAT signaling pathway, Neuroinflammation, Synaptic plasticity, Depression, Alzheimer's disease 0 引言 从结构上看,JAK-STAT信号通路由跨膜受体、受体相关的胞质酪氨酸激酶(Janus kinase, JAKs)、信号转导器和转录激活因子(Signal transducers and activators of transcription, STATs) 三部分组成。JAK ...
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer Article Open access 19 May 2023 The JAK/STAT signaling pathway: from bench to clinic Article Open access 26 November 2021 JAK-STAT signaling maintains homeostasis in T cells and macrophages Article Open acce...
JAK/STATconstitutequarterThe Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway was discovered more than a quarter-century ago.As a fulcrum of many vital cellular processes,the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the...
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway serves as a paradigm for signal transduction from the extracellular environment to the nucleus. It plays a pivotal role in physiological functions, such as hematopoiesis
Control mechanism of JAK/STAT signal transduction pathway. FEBS Lett 2003; 534:190-6; PMID:12527385; http:// dx.doi.org/10.1016/S0014-5793(02)03842-5Yamada, S., Shiono, S., Joo, A. and Yoshimura, A.: 'Control mechanism of JAK/STAT signal transduction pathway', FEBS Lett, 2003, ...