1. Ananthakrishnan R, Hallam K, LiQ,Ramasamy R. JAK-STAT pathway in cardiac ischemic stress. Vascul Pharmacol.2005Oct 28; PubMed ID: 16260187 2. Walker JG, SMith MD. The Jak-STAT pathwayin rheumatoid arthritis. J. Rheumatol. 2005 Sep;32(9):1650-3. PubMedID:16142855 3. Marrero MB. ...
其中JAK1、JAK2和TYK2在人体各组织细胞中均有表达,JAK3主要表达于各造血组织细胞。 作为JAK-STAT信号通路的核心,JAK家族激酶参与了细胞增殖、分化、凋亡以及免疫调节等多种重要的生物学过程。因此,只要抑制JAK激酶,就可以阻碍相关肿瘤、血液系统疾病、类风湿性关节炎等...
为了进一步理解JAK-STAT通路在脑内的作用机制,本文总结了JAK-STAT信号通路在中枢神经系统内的表达分布和功能,为研究JAK-STAT信号通路在脑内的作用以及中枢神经系统疾病提供参考。 关键词:JAK/STAT信号通路;神经炎症;突触可塑性;抑郁症;阿尔兹海默症 中图分类号:R742 The role of JAK-STAT signaling pathway in the ...
Suppression of the JAK/STAT pathway inhibits neuroinflammation in the line 61-PFF mouse model of Parkinson’s disease Huixian Hong Yong Wang Etty N. Benveniste Journal of Neuroinflammation (2024) Hemophagocytic lymphohistiocytosis: current treatment advances, emerging targeted therapy and underlying mech...
Thus the JAK/STAT cascade provides a direct mechanism to translate an extracellular signal into a transcriptional response. In addition to the principal components of the pathway, other effector proteins have been identified that contribute to at least a subset of JAK/STAT signaling events. STAMs (...
(2012) Model-based selection of the robust JAK-STAT activation mechanism. J Theoretical Bio 309: 34-46. O’Shea, J.J., et al. (2004) A new modality for immunosuppression: targeting the JAK/STAT pathway. Nat Rev Drug Discovery 3: 555-564. Liongue, C., et al. (2012) Evolution...
1、抑制JAK-STAT通路可纠正干燥病中的唾液腺炎症和干扰素驱动的免疫激活 Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren's disease Ann Rheum Dis; IF: 27.400; DOI: 10.1136/ard-2023-224842 内容概要: ① 干燥病(SjD)是第二常见的系...
JAK/信号传导及转录激活因子(signal transducers and activators of tranion,STATs) 信号通路是JAK在生物体内介导的最主要的通路,由细胞因子与细胞膜表面的细胞因子受体结合而启动,激活JAK,而后STAT也被激活,并随之转移至细胞核内与靶基因相互作用,从而完成信号传导的过程3,4。(见图2) ...
The Jak/STAT pathway is a putative intracellular signaling pathway that mediates the effects of a large number of cytokines and growth factors. These compounds generally bind to receptors that lack intrinsic kinase activity and thus utilize intracellular enzymes to initiate downstream signaling. This sig...
Thus the JAK/STAT cascade provides a direct mechanism to translate an extracellular signal into a transcriptional response. RTKs (receptor tyrosine kinases) commonly activate Ras/Raf/MEK/ERK signaling but when overactivated can also induce the JAK/STAT pathway, ...