The Janus kinase / signal transducer and activator of transcription (JAK鈥揝TAT) pathway mediates important responses in immune cells. Activation of any of the four JAK family members leads to phosphorylation of one or more of seven STAT family members. Phosphorylation of STAT family members leads...
The cross-talk between the JAK–STAT pathway and other signalling pathways has an important role in regulating immune cells. Abstract The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway has an important role in the control of immune responses. ...
The Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway mediates important responses in immune cells. Activation of any of the four JAK family members leads to phosphorylation of one or more of seven STAT family members. Phosphorylation of STAT family members leads to ...
1,136,137 Numerous studies have shown that cytokine-induced activation of the JAK-STAT pathway plays instrumental roles in the differentiation and development of immune cells and the homeostasis of the immune system (Fig. 2).138,139,140 Under stimulation by different cytokines, the JAK-STAT ...
The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components o... L Hong,CR Dearolf - 《Bioessays》 被引量: 163发表: 2001年 The role of JAK-STAT signaling within the CNS JAK-STAT is an efficient an...
[4] [1]薛翔,刘红梅,邵旦兵, 等.JAK/STAT信号通路调节机制的研究进展[J].现代生物医学进展,2015,15(11):2161-2165. [5]Involvement ofthe JAK-STAT pathway and SOCS3in the regulation ofadiponectin-generated reactive oxygen species in murinemacrophage RAW 264cells. Akifusa S,Kamio N,Shimazaki Y,et...
1、抑制JAK-STAT通路可纠正干燥病中的唾液腺炎症和干扰素驱动的免疫激活 Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren's disease Ann Rheum Dis; IF: 27.400; DOI: 10.1136/ard-2023-224842 内容概要: ① 干燥病(SjD)是第二常见的系...
TF-1 cells were treated with IFN-α, IL-3, or left untreated . Cell lysates were analyzed using the STAT5b [pY699] ELISA kit. Treatment with IFN-α or IL-3 results in activation of the JAK/STAT pathway, as seen by the upregulation of phosphorylated STAT5b. Data was generated us...
3 JAK-STAT信号通路在大脑中的作用 3.1 JAK-STAT信号通路介导的神经细胞增殖分化 大多数脑细胞是在发育过程中由神经干细胞(Neural stem cells, NSCs)或神经祖细胞(Neural progenitor cells, NPCs) 分化形成的,这些细胞可以分化为神经元、星形胶质细胞或少突胶质细胞[19]。JAK-STAT信号通路具有介导NPC增殖分化的作用,...
Janus激酶(JAK)抑制剂是特应性皮炎、银屑病、斑秃和白癜风等皮肤病患者的有效治疗选择,但目前美国食品药品监督管理局(FDA)对口服和外用JAK抑制剂有黑框警告标签,表明其可能会增加患者发生主要不良心血管事件(MACE)、静脉血栓栓塞(VTE)、...