1. Ananthakrishnan R, Hallam K, LiQ,Ramasamy R. JAK-STAT pathway in cardiac ischemic stress. Vascul Pharmacol.2005Oct 28; PubMed ID: 16260187 2. Walker JG, SMith MD. The Jak-STAT pathwayin rheumatoid arthritis. J. Rheumatol. 2005 Sep;32(9):1650-3. PubMedID:16142855 3. Marrero MB. ...
1、典型的 JAK/STAT 信号通路 2、非典型的 JAK/STAT 信号通路 人类疾病中的 JAK / STAT 通路 1、恶性肿瘤 2、炎症和免疫疾病 3、其他疾病 在这个万物皆可卷的社会,信号通路也逃不开内卷!若是不多掌握几项”技能“,治愈更多疾病,迟早也会被科研人员所放弃。那信号通路到底有多内卷呢?今天小陶就给大家介绍一...
2012. ―Functions of the Drosophila JAK- STAT Pathway: Lessons from Stem Cells.‖ JAK-STAT 1 (3): 176-83. doi:10.4161/jkst.21621.Amoyel, M., and E. A. Bach. 2012. Functions of the Drosophila JAK-STAT pathway: lessons from stem cells. jakstat. 1: 176-183....
JAK 与细胞因子受体非共价相关，可介导受体酪氨酸磷酸化，并募集一个或多个 STAT 蛋白，酪氨酸磷酸化的 STATs 二聚，然后通过核膜运输到细胞核，调节特定的基因。虽然部分重叠的细胞因子可以激活 STATs，但不同的 STATs 具有非冗余的生物学效应。JAK/STAT 信号通路深刻地影响了近年来人类对健康和疾病的认识。JAK /...
(2012). JAK/STAT pathway plays a critical role in the proinflammatory 55 56 57 gene expression and apoptosis of RAW264.7 cells induced by trichothecenes... J Tep,B Videmann,M Mazallon,... - 《Toxicology Letters》 被引量: 49发表: 2007年 Inflammatory cytokines regulate microRNA-155 expressio...
[World Health Organization] classification, unlike what has happened with myelodysplastic syndrome.1JAK-STAT signaling is a hallmark of MPN pathogenesis, and all of the mutations that we're aware of at the moment—JAK2,CALR[calreticulin], andMPL—function in the JAK-STAT pathway. MPL is the ...
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus sig
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway The family of cytokines signalling through the common receptor subunit gp130 comprises interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M... HEINRICH, Peter C.,BEHRMANN, Iris,MüLLER-NEWEN, Gerhard,... ...
1、抑制JAK-STAT通路可纠正干燥病中的唾液腺炎症和干扰素驱动的免疫激活 Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren's disease Ann Rheum Dis; IF: 27.400; DOI: 10.1136/ard-2023-224842 内容概要: ① 干燥病(SjD)是第二常见的系...
2015. Function of the chon- drocyte PI-3 kinase-Akt signaling pathway is stimulus de- ... MA Greene,RF Loeser - 《Osteoarthritis & Cartilage》 被引量: 14发表: 2015年 The JAK/STAT pathway but not the Erk1/2 pathway mediates IL-6/sIL-6R downregulation of type II collagen, aggrecan ...