干扰素刺激基因15(ISG15)是一种干扰素(IFN)-α/β-可诱导的,细胞内泛素样蛋白。以往研究发现,小鼠体内的各种蛋白质的ISG15化(ISGylation)促进抗病毒免疫。 本研究发现,某些具有ISG15遗传性缺陷和结核分枝杆菌感染,但不伴有病毒感染的患者。缺乏细胞内ISG15,没有蛋白的ISGy化修饰与细胞对病毒的易感性无关。这与...
In breast cancer, it has been proposed that downregulation of ISG15 inhibits proliferation and migration of these cells [6,28]. Moreover, it has been suggested that protein ISGylation has pro-tumor effects, while free ISG15 has anti-tumor functions [5]. Type I IFNs α and β have been...
Inhibition of ISG15 expression dramatically attenuated clone and sphere formation of ATC cells, and facilitated its sensitivity to doxorubicin. Notably, overexpression of ISGylation, but not the non-ISGylation mutant, effectively reinforced cancer stem cell-like characteristics. Mechanistically, ISG15 ...
encodes a ubiquitin-like protein that functions as a protein modifier via the ISGylation system.Furthermore,non-conjugated ISG15 acts as a cytokine-like protein.In this viewpoint,the interplay between free ISG15,protein ISGylation,and cytoskeletal dynamics in the tumor microenvironment is discussed...
Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity 2021, Cellular and Molecular Immunology Type I Interferonopathies in Children: An Overview 2021, Frontiers in Pediatrics ISG15 and ISGylation in Human Diseases 2022, Cells View all citing articles on Scopus ...
While eliminating this subpopulation of cells would theoretically result in tumor eradication, PaCSCs are extremely plastic and can successfully adapt to targeted therapies. In this study, we demonstrate that PaCSCs increase expression of interferon-stimulated gene 15 (ISG15) and protein ISGylation, ...
and emphasize new insights into the different roles of ISG15/ISGylation in cancer progression. This review may contribute to therapeutic intervention in cancer. However, due to the limitations of current research, the regulation of ISG15/ISGylation on cancer progression is not completely clear, th...
E. Interferon-stimulated gene 15 and the protein ISGylation system. J. Interferon Cytokine Res. 31, 119–130 (2011). CAS PubMed PubMed Central Google Scholar Giannakopoulos, N. V. et al. Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem. Biophys...
and molecular consequences of ISG15 and ISGylation. We also highlight new insights into the roles of ISG15 and ISGylation not only in physiology but also in the pathogenesis of various human diseases, especially in cancer, which could contribute to therapeutic intervention in human diseases. ...
BACKGROUND: ISG15 is an Ubiquitin-like protein, highly induced by Type I Interferons. Upon the cooperative activity of specific Ubiquitinating enzymes, ISG15 can be conjugated to its substrates. Increasing evidence points to a role for protein ISGylation in anti-viral and anti-tumoral defense. ...