干扰素(interferon,IFN)是一种分泌型细胞因子,在抗病毒等免疫反应中发挥关键作用。脊椎动物干扰素家族可分为4个类型,包括I、II、III及最近报道的IV型。干扰素通过结合干扰素受体,诱导超过300个干扰素刺激基因(IFN-stimulated genes,ISGs)参与...
Imaizumi T;Yoshida H;Hayakari R;.Interferon-stimulated gene (ISG)60,as well as 1SG56 and ISG54,positively regulates TLR3/IFN-β/STAT1 axis in U373MG human astrocytoma cells.Neurosci Res.2016.35-41Imaizumi T, Yoshida H, Hayakari R, Xing F, Wang L, Matsumiya T, Tanji K, Kawaguchi S,...
Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy. Ann Neurol. 2010;67(1):53-63.Salajegheh M, Kong SW, Pinkus JL, et al. Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy...
andrevives its research progress.[Key words] ISG15;Antiviral infection;ISGylated;Natural immunity1 ISG15概述干扰素刺激基因 15(interferon stimulated gene15,ISG15)最初于1979年在IFN处理后的细胞中被发现,这种蛋白在合成之初表现为17 kD的前体形式,但随后被水解为 15 kD 的蛋白,因此被命名为“15 kD蛋白”...
ISG15, Interferon-stimulated gene 15, was one ubiquitin-like protein that acted an antiviral agent in the immune system by regulating interferon signals or binding viral proteins to prevent its replication [15, 16]. The structure of ubiquitin-like proteins was similar to that of ubiquitin in tha...
a, IFNs are known to stimulate the JAK-STAT pathway to induce a number of interferon-stimulated genes including ISG15, UbE1L, UbcH8, and Herc5 that lead to the ISGylation process and UBP43 that deconjugates ISGylated proteins. b, the Lys63-linked di-Ub-like protein ISG15 conjugates ...
1ISG15概述 干扰素刺激基因15（interferon stimulated gene 15，ISG15）最初于1979年在IFN处理后的细胞中被发现，这种蛋白在合成之初表现为17kD的前体形式，但随后被水解为15kD的蛋白，因此被命名为“15kD蛋白”。1987年，在发现其转录由IFN-β驱动后，将其更名为“ISG15”［1］。晶体结构显示，ISG15由2个类泛素...
线。I型干扰素(interferon,IFN)是关键的抗病毒细 胞因子,它在细胞建立抗病毒状态的过程中发挥了核 心的作用。I型干扰素与其受体结合后激活酪氨酸 激酶JAK-STAT信号通路,最终诱导干扰素刺激基因 (interferonstimulatedgenes,ISGs)的表达。在众多 的干扰素刺激基因中,isg15是第一个被鉴定出来的 ...
ISG56（Interferon-stimulated genes 56）家族蛋白就是一类干扰素诱导蛋白，以往的研究表明，该家族蛋白具有识别病毒核酸，抑制翻译，抑制细胞迁移和促进细胞凋亡等多种功能，然而其分子机制尚不清楚。结构预测显示ISG56家族蛋白由串联的TPR（tetratricopeptide repeat）结构域组成，能够形成超螺旋结构。利用X射线晶体学的方法，...