Interferon-stimulated genes (ISGs) are the effectors of interferon (IFN) actions and play major roles in innate immune defense against microbial infection. During virus infection, ISGs impart antiviral actions to control virus replication and spread but can also contribute to disease pathology if ...
Viral infection elicits the type I interferon (IFN-I) response in host cells and subsequently inhibits viral infection through inducing hundreds of IFN-stimulated genes (ISGs) that counteract many steps in the virus life cycle. However, most of ISGs have unclear functions and mechanisms in viral ...
antiviral factors involved in innate immune responses that inhibit L1 retrotransposition by destabilizing L1 RNA, L1 proteins, L1 RNPs, and perhaps L1 (-) strand cDNAs (see “Results”: “Proteins produced by Interferon-Stimulated Genes (ISGs) as potential L1 regulators” for a complete list)....
Scientists at Sanford Burnham Prebys have identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes COVID-19. The researchers identified 65 interferon-stimulated genes (ISGs) that act to dampen the infection. The studywas published in the journalMolecular C...
Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the...
Figures (15) Show 9 more figures Tables (1) Table Extras (2) Download all Table S1. List of cellular clusters determined using the tSNE algorithm, related to Figure S7 Table S2. List of genes used for the heatmap shown in Figure S7B, related to Figure S7Volume...
Figure 3. Promoters of Genes Repressed by IFN-γ Maintain Open Chromatin (A) Distribution of average ATAC-seq signal at DE-associated promoters (red, upper panel) or LE-associated promoters (blue, lower panel) in resting (R, dotted line) and IFN-γ-stimulated (G, solid line) macrophages....
Overall, the results are considered robust because 128 of the compiled, curated list of 193 regulated genes were detected by two, or more, of the technologies. Introduction The interferon (IFN) response is one of the most impor- tant arms of host innate immunity against virus infection [1, ...
Nicastrin haploinsufficiency alters expression of type I interferon‐stimulated genes: the relationship to familial hidradenitis suppurativadoi:10.1111/ced.13906Background Hidradenitis suppurativa (HS), also called acne inversa, is a chronic skin disease. The symptoms can be severe, and include intensely ...
Here, we screen a library of nearly 400 interferon-stimulated genes (ISGs) against a biologically contained Ebola virus and identify several ISGs not previously known to affect Ebola virus infection. Overexpression of the top ten ISGs attenuates virus titers by up to 1000-fold. Mechanistic studies...