(1995). Induction of expression of interferon- stimulated gene factor-3 (ISGF-3) proteins by interferons. Exp. Cell Res. 216, 143-148.Rakesh Kumar,Laxminarayana Korutla.Induction of Expression of Interferon-Stimulated Gene Factor-3 (ISGF-3) Proteins by Interferons[J]. Experimental Cell ...
We then investigated whether the recruitment of PCGF3 to ISRE prevents the binding of the interferon-stimulated gene factor 3 (ISGF3) complex (STAT1/STAT2/IRF9) to ISRE. ChIP-qPCR assay showed that p-STAT1 bound more strongly to the promoter regulatory regions of the ISG genes inPcgf3−...
Suppression of enhanced production of interferon-stimulated gene factor 3gamma (ISGF3gamma) in infected cell cultures by antisense oligonucleotide treatment reduced the level of HLA-I. Blocking antibodies to beta interferon (IFN-beta) inhibited the Chlamydia-induced enhancement of both ISGF3gamma and ...
Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like pleiotropic protein and one of the most abundant ISGs, has been studied extensively; however, its roles in SARS-CoV-2 and other viral infections have just begun to be elucidated. Emerging evidence suggests that ISG15 – either in...
Because the L1 5′UTR also contains multiple transcription factor binding sites that drive L1 expression, it remains possible that HELZ2 might repress L1 transcription21,22,110,111,112. Intriguingly, we found that L1 RNAs containing 5′UTR sequences appear to be particularly susceptible to HELZ2...
and then were lysed in 1× passive lysis buffer for 30 min. The supernatant was used to detect the luciferase using luciferase substrate kit on the machine of SpectraMax. Mouse macrophage colony-stimulating factor (M-CSF) was purchased from PeproTech. Recombinant mouse IFN-α was purchased from...
Primary leukemia cells resistant to alpha-interferon in vitro are defective in the activation of the DNA-binding factor interferon-stimulated gene factor 3. 1994. Primary leukemia cells resistant to alpha-interferon in vitro are defective in the activation of the DNA-binding factor interferon-...
Stirnweiss A, Ksienzyk A, Klages K, Rand U, Grashoff M, Hauser H, Kroger A (2010) IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. J Immunol 184:5179–5185 25. Interferome http://interferome.its.monash.edu.au. Accessed 26 Apr 2016 26....
Lymphovascular invasion (LVI) is a prognostic factor in early-stage invasive breast cancer (BC). Through bioinformatics, data analyses of multiple BC cohorts revealed the positive association between interferon-stimulated gene 15 ( ISG15 ) LVI status. Thus, we explored the prognostic significance of...
Transcriptome analyses have recently identified PARP12, a member of a large family of ADP-ribosyl transferases, as an interferon-induced gene (ISG), whose function remains incompletely characterized. We demonstrate herein that PARP12 is a genuine ISG, whose expressed protein displays at least two ...