antiviral factors involved in innate immune responses that inhibit L1 retrotransposition by destabilizing L1 RNA, L1 proteins, L1 RNPs, and perhaps L1 (-) strand cDNAs (see “Results”: “Proteins produced by Interferon-Stimulated Genes (ISGs) as potential L1 regulators” for a complete list)....
Overall, the results are considered robust because 128 of the compiled, curated list of 193 regulated genes were detected by two, or more, of the technologies. Introduction The interferon (IFN) response is one of the most impor- tant arms of host innate immunity against virus infection [1, ...
To obtain a more comprehensive list and abetter understanding of the genes regulated by IFNs, we compiled datafrom many experiments, using two different microarray formats. Thecombined data sets identified >300 IFN-stimulated genes (ISGs). Toprovide new insight into IFN-induced cellular phenotypes,...
IFNs bind to their heterodimeric receptors to initiate downstream cascade of signaling, leading to the up-regulation of interferon-stimulated genes (ISGs). ISGs play very important roles in innate immunity through a variety of mechanisms. Although hundreds of ISGs have been identified, it is ...
Interferons (IFNs) are a family of multifunctional cytokines that activate transcription of subsets of genes. The gene products induced by IFNs are responsible for IFN antiviral, antiproliferative, and immunomodulatory properties. To obtain a more comprehensive list and a better understanding of the ...
Calu-3 cells, a human lung epithelial cell line, are treated with type I IFN to define a consensus list of IFN responsive genes. These genes are then examined in the context of virus infections to evaluate the global ISG response. SARS-CoV and IAV H5N1 utilize contrasting approaches to ...
Overall, the results are considered robust because 128 of the compiled, curated list of 193 regulated genes were detected by two, or more, of the technologies. Introduction The interferon (IFN) response is one of the most impor- tant arms of host innate immunity against virus infection [1, ...
Calu-3 cells, a human lung epithelial cell line, are treated with type I \\{IFN\\} to define a consensus list of \\{IFN\\} responsive genes. These genes are then examined in the context of virus infections to evaluate the global \\{ISG\\} response. Results SARS-CoV and \\{IAV\...
Overall, the results are considered robust because 128 of the compiled, curated list of 193 regulated genes were detected by two, or more, of the technologies.Introduction The interferon (IFN) response is one of the most important arms of host innate immunity against virus infection [1, 2]....