上次与大家分享了干扰素基因刺激因子(stimulator of interferon genes, STING)的在肿瘤方面的相关研究及生信分析的新方向。 概普生信:Nature新热点分享:干扰素刺激因子(STING)那么两年连登Nature的STING有何魅…
干扰素基因刺激因子|Stimulator of Interferon Genes STING(干扰素基因刺激因子)是一种定位于内质网的跨膜蛋白,在环二核苷酸(CDN)的直接结合下发生构象变化,导致下游信号级联,涉及TBK1激活、IRF-3磷酸化和IFN-β及其他细胞因子的产生。 STING是一种环状二核苷酸的模式识别受体,也是一种天然的免疫衔接蛋白,能够从细胞质...
The identification of Stimulator ofInterferonGenes (STING) as a key cytoplasmic innate recognition molecule for DNA viruses whose function is lost in various cancers has coincided with the approval of IMLYGIC formetastatic melanoma. This represents the first replication-competentviral therapyapproved for ...
Detection of cytoplasmic DNA by the host’s innate immune system is essential for microbial and endogenous pathogen recognition. In mammalian cells, an important sensor is the stimulator of interferon genes (STING) protein, which upon activation by bacterially-derived cyclic dinucleotides (cDNs) or c...
Recently, the stimulator of interferon genes (STING) pathway and type I interferons, its downstream molecules, have been reported to be involved in the neurodegenerative process and to be activated in astrocytes. This study aimed to investigate the role of the STING pathway in the pathogenesis of...
中文名称: D61|||STIMULATOR OF INTERFERON GENES AGONIST D61 中文同义词: D61|||STIMULATOR OF INTERFERON GENES AGONIST D61;化合物 STING AGONIST D61 英文名称: STING Agonist D61 英文同义词: STING Agonist D61 CAS号: 2850251-27-1 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏...
2.Expression of B lymphocyte stimulator in peripheral blood mononuclear cells in individuals with systemic lupus erythematosus and the role of interferon-γ on it s expression;IFN-γ对系统性红斑狼疮患者外周血单个核细胞B细胞刺激因子表达的调控 3.AIM: To clone and express soluble B lymphocyte stimulato...
摘要: Interleukin (IL)-15 is a potent T-cell stimulating factor, which has recently been used for preclinical in vivo immunotherapy. Previously we showed that IL-15 induced T-cell Interferon (IFN)-y production via upregulation of endogenous IL-12 synthesis in antigen presenting cells (Krholz ...
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-...
Human CD46 enhances nitric oxide production in mouse macrophages in response to measles virus infection in the presence of gamma interferon: dependence on the CD46 cytoplasmic domains J. Virol., 73 (1999), pp. 4776-4785 CrossrefView in ScopusGoogle Scholar 〚46〛 M. Kruse, E. Meinl, G...