Rakesh Kumar,Laxminarayana Korutla.Induction of Expression of Interferon-Stimulated Gene Factor-3 (ISGF-3) Proteins by Interferons[J]. Experimental Cell Research .1995(1)Kumar R, Kortula L 1995 Induction of expression of interferon-stimulated gene factor-3 (ISGF-3) proteins by interferons. Exp...
Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like pleiotropic protein and one of the most abundant ISGs, has been studied extensively; however, its roles in SARS-CoV-2 and other viral infections have just begun to be elucidated. Emerging evidence suggests that ISG15 – either in...
Suppression of enhanced production of interferon-stimulated gene factor 3gamma (ISGF3gamma) in infected cell cultures by antisense oligonucleotide treatment reduced the level of HLA-I. Blocking antibodies to beta interferon (IFN-beta) inhibited the Chlamydia-induced enhancement of both ISGF3gamma and ...
We then investigated whether the recruitment of PCGF3 to ISRE prevents the binding of the interferon-stimulated gene factor 3 (ISGF3) complex (STAT1/STAT2/IRF9) to ISRE. ChIP-qPCR assay showed that p-STAT1 bound more strongly to the promoter regulatory regions of the ISG genes inPcgf3−...
Because the L1 5′UTR also contains multiple transcription factor binding sites that drive L1 expression, it remains possible that HELZ2 might repress L1 transcription21,22,110,111,112. Intriguingly, we found that L1 RNAs containing 5′UTR sequences appear to be particularly susceptible to HELZ2...
英文名称:Human ISG15 (Interferon Stimulated Gene 15) ELISA Kit 中文名称:人干扰素刺激基因15(ISG15)试剂盒 编号:FS-E0008 实验仪器:酶标仪、洗板机、离心机、培养箱等 试剂盒检测:操作简单、快速、敏感性高、特异性强 规格:96T/48T 注意事项:实验开始前,将人巨噬细胞来源的趋化因子试剂盒先从冰箱中拿出来...
Abstract Microglia, the resident immune cells of the brain, regulate neuroinflammation which can lead to secondary neuronal damage and cognitive impairment under pathological conditions. Two of the many molecules that can elicit an inflammatory response from microglia are lipopolysaccharide (LPS), a compon...
Signal transducer and activator of transcription 3 (STAT3) is a multifunctional factor that regulates immunity and the inflammatory response. The protective role of STAT3 is reported in Coxsackievirus B3 (CVB3)-induced cardiac fibrosis, yet the exact role of STAT3 in modulating viral-induced STAT1 ...
gene expression changes upon IFN-γ-treatment and on the alterations to the pattern by further addition of AX-0085. Significantly up-regulated and down-regulated genes from IFN-γ-treatment alone were subjected to gene set analyses. Most notably, top up-regulated GO terms included ‘response to...
而在I型干扰素信号中,STAT1-STAT2异二聚体结合IRF9(Interferon Response Factor,干扰素响应因子)组成ISGF3(Interferon Stimulated Gene Factor,干扰素基因激活因子)再结合到ISRE(Interferon-Stimulated Response Element,干扰素激活反应元件)启动子激活ISG的表达。 LASER-wikipedia2 White blood cells may be a source ...