Definition Cerebral small vessel ischemic disease (SVID) results from compromised functioning of the small penetrating cerebral arteries, causing reduced blood flow to deep white matter regions of the brain, leading to focal lacunar infarcts, diffuse ischemia (leukoaraiosis), vascular cognitive ...
Alzheimer’s disease and small vessel ischemic disease frequently co-exist in the aging brain. However, pathogenic links between these 2 disorders are yet to be identified. Therefore we used Taqman genotyping, exome and RNA sequencing to investigate Alzheimer’s disease known pathogenic variants and ...
Conclusions: The present results suggest that the NIHSS cannot reflect the extent of neurological deficit and clinical severity in subjects with lacunar infarctions in the context of a chronic and diffuse small vessel disease. A specific and global neurological scale, including the assessment of ...
摘要: OBJECTIVE: In patients with acute ischemic stroke, we aimed to investigate the relation between preexisting small vessel disease (SVD) and the amount of blood-brain barrier (BBB) leakage in ischemic and nonischemic area before IV thrombolysis....
CONCLUSIONS: Cerebral small vessel disease, with or without a history of cerebrovascular disease, is associated with increased risk of death and ischemic stroke in patients with atherosclerotic disease. 展开 关键词: Humans Cerebrovascular Disorders Brain Ischemia Magnetic Resonance Imaging Risk Factors ...
Atrial fibrillation increases the risk of clots forming in the heart that can then travels to the brain. Risk factors of ischemic stroke You're more likely to have an ischemic stroke if you: Are over age 60 Have high blood pressure, heart disease, high cholesterol, or diabetes Have an ...
Frontal lobe atrophy is associated with small vessel disease in ischemic stroke patientsdoi:10.1016/j.clineuro.2009.08.019Frontal lobeAtrophyStrokeSmall vessel diseaseMRIWhite matter lesionsBackground The pathogenesis of frontal lobe atrophy (FLA) in stroke patients is unclear. We aimed to ascertain ...
1). Small-vessel disease (SVD) etiology remained as a protective factor against mortality [p = 0.020; OR = 0.09 (95% CI: 0.01–0.68], taking as reference large-artery atherosclerosis (LAA). Given that age-related changes in blood cell composition are well documented, model 3 ...
Frey BM, Petersen M, Schlemm E, Mayer C, Hanning U, Engelke K, Fiehler J, Borof K, Jagodzinski A, Gerloff C, Thomalla G, Cheng B (2020) White matter integrity and structural brain network topology in cerebral small vessel disease: the Hamburg city health study. Hum Brain Mapp 42:14...
Small vessel occlusion (e.g., lacunar infarct) (∼ 20%): see “Subtypes and variants” below. Global cerebral ischemia Systemic hypoperfusion Shock or bilateral large artery atherosclerosis (e.g., of carotid arteries)→ decreased effective oxygen delivery to the whole brain Common during cardia...