Topoisomerase IIbeta (Top2b) is an enzyme that modulates DNA supercoiling by catalyzing the passage of DNA duplexes through one another. It is ubiquitously expressed in postmitotic cells and known to function during the development of neuromuscular junctions in the diaphragm and the proper formation...
Topoisomerase II (topo II) is an essential enzyme that alters DNA topology. This activity is important for a variety of chromosome functions including DNA replication, transcription, recombination, and chromosome condensation and segregation. Previously we localized topo II in mouse gametes and ...
Our results suggest that topoisomerase II may be an enzyme that is also a structural protein of interphase nuclei and mitotic chromosomes. 展开 关键词: Animals Cell Nucleus DNA Topoisomerases, Type I Cell Fractionation Mitosis Interphase Chickens Chromosomes Molecular Weight ...
These results suggest that CoSAL shows a bidirectional mode of interaction with enzyme and DNA and inhibits topoisomerase II activity by forming a drug-mediated cleavage complex. Our data strongly suggest that topoisomerase II may be one of the cellular targets for antiproliferation activity of CoSAL...
Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein. The N-terminus of human topoisomerase I participates in the binding of this enzyme to helicases and other proteins. Using the N-terminal 250 amino acids of... P,Haluska,A,... - 《Nucleic Acids Research...
Human topoisomerase I (topo I) is an essential cellular enzyme that relaxes DNA supercoiling. The 6.3 kDa C-terminal domain of topo I contains the active site tyrosine (Tyr723) but lacks enzymatic activity by itself. Activity can be fully reconstituted when the C-terminal domain is associated...
Enzyme activtors positively regulate an enzyme's activity. What this means is that the activator acts as a gatekeeper for a reaction. It tells the...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your tough ...
DNA topoisomerase II (Topo II) is an essential nuclear enzyme and a validated target for anticancer agent screening. CS1, a novel 2-phenylnaphthalene, had ... Tanner,M. - 《Journal of Clinical Oncology》 被引量: 250发表: 2006年 Topoisomerase-IIα expression as a predictive marker in a pop...
Molecular Analysis of Yeast and Human Type II Topoisomerases ENZYME-DNA AND DRUG INTERACTIONS The DNA sequence selectivity of topoisomerase II (top2)-DNA cleavage complexes was examined for the human (top2alpha), yeast, and Escherichia coli (i.e. gy... D Strumberg,JL Nitiss,J Dong,... ...
a) Topoisomerase b) Gyrase c) Nucellase d) Helicase Nucleic Acid: The nucleic acids DNA is the primary molecule containing an organism's genetic material. DNA holds the genetic code of organisms which is transcribed into RNA ...