doi:10.1016/0169-5002(95)96402-HELSEVIERLung Cancer
A cutoff labeling index of 12% was found to define 2 prognostic subgroups (TIIα <12 vs. ≥12) with profoundly different 5‐year progression‐free survival (60% vs. 8%; p = 0.0108, log‐rank test) and overall survival (100% vs. 8%; p = 0.0038) rates. TIIα expression was ...
While the chromosome-damaging effects of etoposide, a topo II poison, have been proposed to act through a threshold mechanism, little is known about the chromosome damaging effects and dose responses for the catalytic inhibitors of the enzyme. The current study was designed to further investigate ...
The primary endpoint of this study, being conducted in the United States and Europe, is overall survival (OS), with a projected 243 patients enrolled in a 2:1 randomization design (Berubicin:Lomustine). This study has pharmacokinetic (PK) evaluations of all patients enrolled, with at least...
N-ACYL-DEMETHYLCOLCHICINE DERIVATIVES AND THEIR USE AS MAMMALIAN DNA TOPOISOMERASE II INHIBITORSKuoHsiung LEEBASTOW, Kenneth, F
2:395-400.O'Connor PM, Kerrigan D, Bertrand R, Kohn KW, Pommier Y. 10,11-Methylenedioxycamptothecin, a topoisomerase I inhibitor of increased potency: DNA damage and correlation to cytotoxicity in human colon carcinoma (HT-29) cells. Cancer Commun. 1990; 2 (12):395–400....
Patients with severe disease appeared to be younger (mean age 50 vs 55 yr), more often non-caucasian (51 vs 12%), with a longer time since non-Raynaud (median 4 vs 2 yr) and more often diffuse skin involvement (dcSSc;62 vs 41%), calcinosis (6 vs 0%) and weight loss (23 vs ...
The phase I study of single administration of NB-506 has been finished and the maximum tolerated dose was decided to be 180 mg/m2. The phase I study of 5 days divided dose of NB-506 is on going. The maximum tolerated dose seems to be less than 450 mg/m2. Dose limiting toxicities ...
nutrients Article Cuminaldehyde from Cinnamomum verum Induces Cell Death through Targeting Topoisomerase 1 and 2 in Human Colorectal Adenocarcinoma COLO 205 Cells Kuen-daw Tsai 1,2,3, Yi-Heng Liu 1, Ta-Wei Chen 1, Shu-Mei Yang 1,2, Ho-Yiu Wong 1, Jonathan Cherng 4, Kuo-Shen Chou 5 ...
2; DNA double-strand breaks (DSBs); DSB repair; 51 strand resection; 51 adducts; Mre11; CtIP; DNA2 The double-helical structure of DNA dictates that topological strains are generated by replication forks and transcription machineries as they plow between the two intertwined strands [1]. An...