Several recent studies used results of SARS-CoV-2 RT-qPCR, Ct (threshold cycle), as proxies of viral load1. Unfortunately, an important aspect of this virus' biology is neglected: Coronaviruses being (+)ssRNA viruses the form of RNA they use for replication is identical to the form used ...
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence Article Open access 09 March 2023 SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses Article 17 January 2023 SARS-CoV-2...
SARS-CoV-2 RNA levels in the rectal swabs were overall the lowest. From each SARS-CoV-2 RNA positive animal, infectious virus was isolated in VeroE6 cells from throat and nasal swabs for at least two consecutive days (Supplementary Fig. 2 and Supplementary Table 1). In contrast, no ...
In late 2019, an outbreak of a new coronavirus (CoV) was reported, which quickly became a pandemic [1]. This new CoV virus is called SARS-CoV-2 and causes the coronavirus disease, COVID-19 [2]. In the healthiest people, the majority of COVID-19 infections are asymptomatic, mild or ...
Background Tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral ribonucleic acid (RNA), using reverse transcription polymerase chain reaction (RT-PCR) are pivotal to detecting current coronavirus disease (COVID-19) and duration of detectable virus indicating potential for infec...
Moreover, they showed that the virus can replicate in intestinal epithelial cell lines as well as in human colon organoid models, therefore participating in the spread and enhanced viremia of SARS-CoV-2 [34], [35]. Overall, SARS-CoV-2 has an intestinal tropism and may induce acute ...
Upper respiratory tract SARS-CoV-2 RNA loads in symptomatic and asymptomatic children and adults. Clin Microbiol Infect. 2021;27:P1858.E1–E7. Article Google Scholar Brown CM, et al. Outbreak of SARS-CoV-2 infections, including COVID-19 vaccine breakthrough infections, associated with Large ...
Veklury is a SARS-CoV-2 nucleotide analog RNA polymerase inhibitor, an antiviral agent that stops replication of the virus. Previously remdesivir was available only via an emergency use authorization (EUA) to treat COVID-19. Veklury is approved for use in patients 12 years of age and older...
The SARS-CoV-2 nucleocapsid (N) protein is an abundant RNA-binding protein critical for viral genome packaging, yet the molecular details that underlie this process are poorly understood. Here we combine single-molecule spectroscopy with all-atom simulations to uncover the molecular details that cont...
SARS-CoV-2 virus particles at 48 h post treatment of molnupiravir (n = 4–5).dImmunofluorescence staining of nucleocapsid protein of SARS-CoV-2. Scale bar, 50 μm.eThe effects of nirmatrelvir on intracellular viral RNA levels of WT and Omicron SARS-CoV-2 (n = 4–6)...