Prostate cancer is the most frequently diagnosed solid organ cancer in men and is the second leading cause of cancer-related deaths in men in the United Ki...vekri
“Today, our goal in treating men with advanced prostate cancer is to control, not cure,” says Dr. Chatta. That means physicians and patients alike focus on treatments that’ll help to shrink the tumor and control symptoms. Even though a cure is not yet in the cards for advanced prostate...
Prostate cancer (PC) represents a global health issue. Treatment for locally advanced and metastatic PC remains unsatisfactory. The androgen receptor (AR) has been validated in having a key role in both naïve and castrate-resistant PC (CRPC). However, the significance of other signalling pathwa...
Abstract 214: Androgen resistance in prostate cancer is associated with an enrichment of stem-like cells Cancer Stem cells (CSCs) or tumor initiating cells (TICs) have recently been identified in solid tumors; however, the role of CSCs/TICs in metastasis remains poorly understood. In this study...
Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and the immunosuppressive nature of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components of the TME.
Tumor angiogenesis: The VEGF signalling system is a novel target for prostate cancer therapy 来自 ResearchGate 喜欢 0 阅读量: 21 作者: D. Marmé 摘要: The growth of solid tumors and the formation of metastases are dependent on the formation of new blood vessels. Solid tumors have their ...
The adipose expansion has remarkable similarities with the growth of solid tumors. These similarities are the following: (1) The capability to unlimited expansion; (2) Reversible plasticity; (3) Induction of angiogenesis; (4) Chronic inflammation; (5) Remodeling and disfunction; (6) Systemic ...
AXL, a TAM tyrosine kinase receptor, plays an essential role in the pathogenesis of various solid tumours. This study explores the role of AXL and its ligand PROS1 in the generation and biological behaviour of papillary thyroid cancer (PTC). The expressi
However, MYCN regulation of the molecular clock and its effects on tumor phenotype remain largely unknown. The clock activator RORα has been identified as a putative tumor suppressor and is repressed in many cancer types20,21,22,23. Mechanistically, RORα acts by inducing SEMA3F20 and p53 ...
Molecular sampling of prostate cancer: a dilemma for predicting disease progression The determination of the molecularly dominant tumor nodule may be limited by sampling at time of initial diagnosis, may not be present at time of initial d... A Sboner,F Demichelis,S Calza,... - 《Bmc Medica...