Prostate cancer: Tumour genomes are highly plasticdoi:10.1038/nrurol.2016.132StoneLouiseNature Reviews Urology
Prostate canceris a common malignancy of males. The normal growth and function of the prostate gland is dependent on androgens, but also members of the TGFβ superfamily. It has been shown that there is loss ofinhibinα subunitexpression in high-gradeprostate cancer(Mellor et al., 1998), and...
et al. IL-23 secreted by myeloid cells drives castration-resistant prostate cancer. Nature 559, 363–369 (2018). This study is the first to demonstrate the IL-23-mediated paracrine effect of tumour-infiltrating MDSCs in driving castration-insensitive prostate cancer growth. Article CAS PubMed ...
In this study, we examined the role of Epo in prostate cancer (PCa) progression, using in vitro cell culture systems and in vivo bone metastatic assays. We found that Epo did not stimulate the proliferation of PCa cell lines, but did protect PCa cells from apoptosis. In animal models of ...
Over the past century, the two main approaches to treating people with cancer — surgery and radiation — have focused on where in the body the tumour is. This has led to medical oncologists and other health-care providers, regulatory agencies, insurance companies, drug firms — and patients ...
In 2023, Steve had a swelling in his cheek. It was diagnosed as parotid cancer. He wrote me and asked for help again. He took our herbs for about three months, but the tumour did not go away. He was okay but had occasional pain. But every morning when Steve woke up, he looked in...
Several of the genes found to have lower expression in DESNT cancer (ACTA2, CNN1, LMOD1) encode proteins primarily expressed in smooth muscle cells or myofibroblast, indicative of an altered tumour-stromal environment. We failed to find a correlation between stromal content and clinical outcome ...
In 1936 prostatic acid phosphatase (PAP) became the key serum marker for monitoring prostate cancer (PCa) treatment (1–3). Approximately 50 yr later, prostate-specific antigen (PSA) emerged as the most useful serum marker for PCa management followed a f
Prostate and other tumours probably arise in the context of pre-existing inflammation which could be actively contributing to tumour progression. Conventional treatments for prostate cancer, such as androgen ablation, have immunological effects that could prove beneficial in terms of supporting an antitumo...
Prostate cancer is the second most common malignancy in men worldwide and consists of a mixture of tumor and non-tumor cell types. To characterize the prostate cancer tumor microenvironment, we perform single-cell RNA-sequencing on prostate biopsies, prostatectomy specimens, and patient-derived organo...