Prostate cancer is the second most common malignancy in men worldwide and consists of a mixture of tumor and non-tumor cell types. To characterize the prostate cancer tumor microenvironment, we perform single-cell RNA-sequencing on prostate biopsies, prostatectomy specimens, and patient-derived organo...
The growth in molecular data on tumors has driven the development of powerful algorithms to sort tumors into classes and clusters8,9,10. These algorithms attempt to maximally separate tumors and cluster them according to molecular criteria. Cluster membership can be correlated with drug response and ...
Fibrous tumor of the pleura (benign); unifocal may be locally invasive • Malignant thymoma and lymphoma often have appearance similar to that of mesothelioma • Metastases: breast, lung, prostate, thyroid, renal • Lipoma (most common benign tumor) • Extrapleural tumors Rib tumors Childre...
These data suggest that some forms of androgen-independent prostate cancer may benefit from a combination therapy of IFN-gamma and TNF-alpha, while the use of IFN-gamma alone may be more efficacious in others. 展开 关键词: Tumor necrosis factor-α Interferon-γ Prostate cancer ...
We assessed the impact of tumor volume, tumor volume ratio (tumor volume-to-prostate volume), surgical experience and type of nerve sparing procedure on biochemical recurrence after laparoscopic radical prostatectomy. Of 1,600 laparoscopic radical prostatectomies performed between March 1999 and May 200...
on the prostate cancer.Methods The growth inhibitory effect of VES and apoptosis was detected by flow-cytometry and fluorescence microscopy.The PCNA index(PI) and the apoptosis index(AI) of VES-treated CAM xenograft tumor was tested by the immunohistochemistry and the Tunel assay.Results VES had ...
There is no effective treatment for bone metastatic prostate cancer. Regucalcin was discovered as a novel inhibitory protein of calcium signaling with calcium-binding properties [12,13]. The regucalcin gene localizes on the X chromosome [14], and its protein expresses in various types of cells ...
We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches. Background Colorectal cancer (CRC) ...
Evidence from physical sciences in oncology increasingly suggests that the interplay between the biophysical tumor microenvironment and genetic regulation has significant impact on tumor progression. Especially, tumor cells and the associated stromal cel
Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of tumors. Most mechanistic studies focus on their static functional status before or after activation, not considering motility as an important characteristic for an