P53 is a tumor suppressor gene[J] . Arnold J. Levine,Cathy A. Finlay,Philip W. Hinds.Cell . 2004Levine AJ, Finlay CA and Hinds PW. P53 is a tumor suppressor gene. Cell 2004; 116 (2 Suppl): S67-69, 61 p following S69.
Munroe D.G., Rovinski B., Bernstein A., Benchimol S. Loss of a highly conserved domain on p53 as a result of gene deletion during Friend virus-induced erythroleukemia Oncogene, 2 (1988), pp. 621-624 View in Scopus Google Scholar ...
可能您是非常英俊的,可能您是非常逗人喜爱的,我可能爱以您。 [translate] aSo, I'm glad to meet you, 如此,我是高兴遇见您, [translate] aThe P53 tumor suppressor gene product is a transcription factor involved in DNA repair. P53肿瘤遏抑器基因产品是在脱氧核糖核酸修理介入的副本因素。 [translate] ...
By analogy, one might suppose that tumor suppressor gene products fulfil similarly essential functions in the integration process. Although this is probably the case for almost all tumor suppressor genes, there may be one exception: p53. The phenotypes of loss-of-function (‘knock-out’) mutant ...
The/gene encodes a ubiquitin ligase implicated in the control of chromosome stability. Here we identify the mousegene as a p53-dependent tumour suppressor gene by using a mammalian genetic screen for p53-dependent genes involved in tumorigenesis. Radiation-induced lymphomas from p53mice, but not tho...
The p53 tumor suppressor gene is regulated in vivo by nuclear factor 1-C2 in the mouse mammary gland during pregnancy. Oncogene. 2003;22(38): 6061 - 6070.Kannius-Janson M, Bjursell G, Nilsson J: The p53 tumor suppressor gene is regulated in vivo by nuclear factor 1-C2 in the mouse ...
Supported by clinical data, our study suggests that RNF144B plays a pivotal role in maintaining genomic stability during tumor suppression. Graphical Abstract Background TP53is recognized as the most frequently mutated gene in human cancers [1,2]. Furthermore, germline heterozygous mutations inTP53ca...
Topoisomerase IIalpha gene expression is regulated by the p53 tumor suppressor gene in nonsmall cell lung carcinoma patients. Cancer. 2002;94(8): 2239–47.Liu D, Huang CL, Kameyama K, Hayashi E, Yamauchi A, Sumitomo S, et al. Topoisomerase IIalpha gene expression is regulated by the p53...
Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis. Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In most cases, the p53 gene is mutated, giving rise to a stable mutant prote... N Rivlin,B Ran,M Oren,......
V. Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene? Schizophr Res 41, 405-415 (2000).Catts VS, Catts SV. Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene? Schizophr Res 2000;41:405- 15....