Proto-oncogenes and tumor suppressor genes are primarily involved in orchestrating normal growth and differentiation – except for p53, which seems to be dedicated to controlling abnormal growth. Introduction Despite the way they were discovered, it is hard to believe that nature has furnished us wit...
et al. The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited. Oncogene 14, 1407–1417 (1997). https://doi.org/10.1038/sj.onc.1200949 Download citation Received01 August 1996 Revised11 November 1996 Accepted12 November ...
Inactivation of the p53 oncogene by internal deletion or retroviral integration in erythroleukemic cell lines induced by Friend leukemia virus Oncogene, 3 (1988), pp. 179-185 Google Scholar Bienz, et al, 1984 Bienz B., Zakut-Houri R., Givol D., Oren M. ...
The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited. Oncogene. 1997 Mar 27;14(12):1407-17Middeler,G., Zerf,K., Jenovai,S., Thulig,A., Tschodrich-Rotter,M., Kubitscheck,U., & Peters,R. (1997) The ...
of cellular senescence by DNA damage A-P Sappino1, R Buser2, Q Seguin3, M Fernet4, L Lesne2, F Gumy-Pause2, W Reith3, V Favaudon4 and SJ Mandriota2 The p53 tumor-suppressor protein has a key role in the induction of cellular senescence, an important barrier to cancer development...
Mutations at the interaction interface that compromise cooperativity were identified in cancer patients, suggesting a requirement of cooperativity for tumor suppression. We report on an analysis of cooperativity mutant p53E177R mice. Apoptotic functions of p53 triggered by \{DNA\} damage and oncogenes...
Oncogene 22:6061-6070Johansson EM, Kannius-Janson M, Bjursell G, Nilsson J: The p53 tumor suppressor gene is regulated in vivo by nuclear factor 1-C2 in the mouse mammary gland during pregnancy. Oncogene 2003, 22(38):6061-6070.The p53 tumor suppressor gene is regulated in vivo by ...
B Ogretmen,AR Safa - 《Oncogene》 被引量: 240发表: 1997年 Regulation of p53: TRIM24 enters the RING Negative regulation of p53 in normal, unstressed cells maintains levels of this tumor suppressor below a threshold for cell cycle arrest or apoptosis, and ... Abhinav,K.,Jain,... - 《...
Toward identifying new strategies to target gastric cancer stem-like cells (CSCs), we evaluated the function of the tumour suppressor CDK5 regulatory subunit-associated protein 3 (CDK5RAP3) in gastric CSC maintenance. We examined the expression of CDK5RA
p53 is a tumor suppressor, which belongs to the p53 family of proteins. The family consists of p53, p63 and p73 proteins, which share similar structure and function. Activation of wild-type p53 or TAp73 in tumors leads to tumor regression, and small molecules restoring the p53 pathway are ...