P53 is a tumor suppressor gene[J] . Arnold J. Levine,Cathy A. Finlay,Philip W. Hinds.Cell . 2004Levine AJ, Finlay CA and Hinds PW. P53 is a tumor suppressor gene. Cell 2004; 116 (2 Suppl): S67-69, 61 p following S69.
Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen Proc. Natl. Acad. Sci. USA, 80 (1983), pp. 56-59 Crossref View in Scopus Google Scholar Parada, et al, 1984 Parada L.F., Land H., Weinberg R.A., Wolf D., Rotter V. ...
Abstract p53 Is a tumor suppressor that integrates signals from different stress induced signalling pathways, regulates cell cycle arrest, senescence, apoptosis and DNA repair. How p53 dictates cell fate is unclear. As a major transcriptional target of p53 in response to cellular stress, p21 i...
Wild-type but not mutant p53 protein bound to oligonucleotides corresponding to this region of the bax promoter, based on gel retardation assays. Taken together, the results suggest that bax is a p53 primary-response gene, presumably involved in a p53-regulated pathway for induction of apoptosis....
p53 is a tumor suppressor, which belongs to the p53 family of proteins. The family consists of p53, p63 and p73 proteins, which share similar structure and function. Activation of wild-type p53 or TAp73 in tumors leads to tumor regression, and small molecules restoring the p53 pathway are ...
p53抑癌基因产物是一种转录因子,参与DNA修复。 翻译结果2复制译文编辑译文朗读译文返回顶部 P53肿瘤抑制基因产品是一种誊写个因素涉及在脱氧核糖核酸的修复。 翻译结果3复制译文编辑译文朗读译文返回顶部 P53 肿瘤抑制基因产物是参与 DNA 的转录因子修复。 翻译结果4复制译文编辑译文朗读译文返回顶部 P53肿瘤抑制基因产品是...
et al. The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited. Oncogene 14, 1407–1417 (1997). https://doi.org/10.1038/sj.onc.1200949 Download citation Received01 August 1996 Revised11 November 1996 Accepted12 November ...
To understand the molecular mechanism of repression of NF-κ;B activity by glucocorticoids, we performed a high-through put siRNA oligo screen to identify novel genes involved in this process. Here, we report that loss of p53, a tumor suppressor protein, impaired repression of NF- κ;B ...
p53 also acts as a tumor suppressor that can induce apoptosis upon serious DNA damage by releasing pro-apoptotic factors from the mitochondria or activating the transcription of pro-apoptotic factors, and it can also induce cell cycle arrest22,23. Upon DNA damage, transcription blockage occurs, ...
Johansson EM, Kannius-Janson M, Bjursell G, Nilsson J: The p53 tumor suppressor gene is regulated in vivo by nuclear factor 1-C2 in the mouse mammary gland during pregnancy. Oncogene 2003, 22(38):6061-6070.The p53 tumor suppressor gene is regulated in vivo by nuclear factor 1-C2 in ...