Explain the molecular mechanisms of three p53-targeted anti-cancer drugs. Does the "two-hit" hypothesis explain the role of oncogenes and proto-oncogenes in cancer? Why or why not? You are a cancer researcher and want to develop a treatment that will preve...
Arsenic trioxide elicits prophylactic and therapeutic immune responses against solid tumors by inducing necroptosis and ferroptosis Cell Mol. Immunol., 20 (1) (2023), pp. 51-64 CrossrefGoogle Scholar [124] R. Kang, G. Kroemer, D. Tang The tumor suppressor protein p53 and the ferroptosis netwo...
Although resistance to cell death is an important feature of cancers, it is certainly not true that tumors are fully resistant to cell death.32If true, anti-cancer therapies would invariably fail. The majority of today’s therapeutic regimens aim to directly kill tumor cells and often successfull...
He observed that tumors required extremely high levels of glucose compared with surrounding normal tissues, and that glycolysis was significantly enhanced tumors, even in the presence of adequate oxygen [2]. It is apparent that the Warburg effect is beneficial to the proliferation and survival of ...
Does apoptosis drive malignant transformation in pre-malignant conditions such as therapy-related myelodysplastic syndromes or congenital bone marrow failure syndromes? Can resistance to apoptosis delay the risk of (further) malignant transformation within fully established tumors or in pre-malignant tissues?
A. (2013). Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors. Proceedings of the National Academy of Sciences of the United States of America, 110(44), E4134–E4141. doi:10.1073/pnas.1317042110. Article PubMed Central CAS PubMed Google Scholar Weaver,...
(Fig. 7A). Although miRNAs have been current main focus as candidate biofluid-based biomarkers, the high stability and abundance of tRFs/tiRNAs in body fluids, the involvement in pathological processes, the demonstrated differential expression in solid tumors and hematological malignancies, and their ...
In enhancing the antitumor activity of adriamycin, NOB inhibits Akt to suppress the Wnt/β-catenin signaling pathway via elevating GSK-3β activity, leading to the reduced viability and proliferation of lung cancer cells [108]. One of the most well-known and studied signaling pathways is the ...
Another pilot study was undertaken to investigate the clinical efficacy of oral curcumin (500 mg) with piperine (5 mg) on the pain and the markers of oxidative stress in patient with pancreatitis, and showed that this oral administration regime was able to suppress the lipid peroxidation in ...
There is a lot of evidence which shows the potential of ginger to prevent and suppress tumors, especially gastrointestinal cancer (GI). Ginger extracts and its individual constituents allow the multitargeted influence on cancer cells affecting Bcl2, p38/MAPK, EGFR, VEGF, AKT, ERK1/2, etc. [...