The p53 suppressor gene. Nature 351: 453, 1991. View ArticleLevine AJ,Momand J,Finlay CA.The p53 suppressor gene. Nature . 1991Levine A!,Momand J, Finlay CA. The p53 suppressor gene. Na- ture 351:453-456, 1991.Levine AJ,Momand J,Finlay CA,et ...
Effectiveness of Waterlettuce as biofilter in liquid waste of leather tanning to decrease organic and inorganic is 99.33% of pH; 100.65% of BOD; 119.70% of DO; 10.16% of TSS and 103.05% of chromium content.Sherring, Matthew AtmoreLung Cancer...
2003 . The p53 tumor suppressor gene is regulated in vivo by nuclear factor 1-C2 in the mouse mammary gland during pregnancy . Oncogene 22 : 6061 – 6070 .Johansson EM, Kannius-Janson M, Bjursell G, Nilsson J. The p53 tumor suppressor gene is regulated in vivo by nuclear factor 1-C2...
p53 was originally considered to be a nuclear oncogene, but several convergent lines of research have indicated that the wild-type gene functions as a tumor suppressor gene negatively regulating the cell cycle. Mutations in the p53 gene have been detected in many tumor types and seem to be the...
The p53 tumor suppressor serves to secure genetic stability of multicellular organisms. It suppresses the accumulation of mutations in somatic cells and substantially decreases the probability of malignant diseases. The p53 gene acts highly selectively through multiple mechanisms. Under relatively favorable ...
Mutation of the p53 tumor suppressor gene, often accompanied by overexpression of mutant p53 protein, is the most frequent molecular genetic event described thus far in human cancers. In adenocarcinomas of the ovary and endometrium, p53 overexpression is seen in approximately 10% to 15% of early ...
The p53 tumor suppressor induces the transcription of genes that negatively regulate progression of the cell cycle in response to DNA damage or other cellular stressors and thus participates in maintaining genome stability. Numerous studies have demonstrated that p53 transcription is activat...
The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors. Chief among the negative regulators is the p53 protein. Alteration or inactivation of p53 by mutation, or by its interactions with oncogen
The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors. Chief among the negative regulators is the p53 protein. Alteration or inactivation of p53 by mutation, or by its interactions with oncogen
Birch JM. Germline mutations in the p53 tumour suppressor gene: scientific, clinical and ethical challenges. Br J Cancer. 1992;66(3):424–6.BIRCH, J.M. (1992). Germline mutations in the p53 tumour suppres- sor gene: scientific, clinical and ethical challenges. Br. J. Cancer, 66, 424-...