The reactions were cooled on ice, neutralized by the addition of 1 N NaOH (1 equivalent) and sedimented (50,000 × g, 10 min). The supernatant fraction was removed and reserved, and the pellet was re-suspended in water and re-sedimented. The supernatant fractions were combined ...
Diazonium salt can be displaced by the nucleophile. The reaction occurs due to the weak bonding between the carbon and the diazochloride group. The coupling reaction of diazonium chloride is also the part of nucleophilic reaction. Answer and Explanation:1 ...
The tosylate group is large and has low $pK_a$ values, making it a good leaving group. A common tosyl compound is tosyl chloride. Complete answer: We have learnt earlier that; resonance stabilized structures are weak bases. Therefore, the leaving groups that form resonance stabilized stru...
Which of the following is a weak base? a. NH3 b. Ca(OH)2 c. Ba(OH)2 d. NaOH e. CH3COOH 1. Which of the following is the strongest acid? a) CH4 b) NH3 c) H2O d) HF 2. Which of the following is the weakest acid? a) HF b) HCl c) HBr d) HI Which of...
In CGI-58, Asn155 replaces the putative active site nucleophile. A large, primarily helical lid region (Pro180–Leu280) is inserted after strand β6 and covers the potential “active site.” An additional feature of the model is a long partly helical, partly unstructured region ranging from...
we repeated the force-quench experiments at pH=7.2 using the small thiol 3-mercapto-1-propanol as the attacking nucleophile41(Supplementary Fig. 11). In this case, the rupture of each individual disulfide bond resulted in the formation of a thiolate and the newly formed mixed disulfide. Unlike...
Because every nucleophile is potentially a base, and vice versa. If you have a reaction where it looks like you might get SN2 or E2, look closely first – is there any chance of a simple acid-base reaction? For instance, take NaOH plus an alkyl thiol, R–SH. Is it an SN2? Or ...
1. Which one is the strongest base? 2. Which one the weakest base? 3. Which one is the nucleophile?Which is the stronger acid: (CH_{3})_{2}OH or (CH_{3})_{2}NHWhich of the following is the strongest Bronsted acid? a) H3COH b) H2SO4 c) HBr d) NH3...