The enzymatic mechanism involves a Zn2+-coordinated water molecule acting as a nucleophile, and a conserved histidine residue, H105, acting as a bifunctional acid/base catalyst. Phylogenetic analysis of PplD homologs in bacterial genomes suggests the occurrence of GlcN 1-phosphate in the ...
one is to dissolve the reactants and the other as an acid or a base or a nucleophile. There...
What is the purpose of adding 40% NaOH solution to the tin reduction mixture ? What is the purpose of hydrogen peroxide in the cobalt complex lab ? What would be the benefit of having a limiting reagent when performing a lab experiment? Why not simply make both reactants go to completion...
An SN2 reaction in organic chemistry is a type of substitution reaction that occurs in a single step with the use of a strong nucleophile. During an...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your toug...
(a) Steady-state kinetic analysis of OMPDC-catalysed conversion of OMP into UMP by isothermal titration calorimetry showing the raw data thermogram after a single injection of 0.2 mM OMP to a solution containing 1 µM OMPDC in 20 mM HEPES/NaOH, pH 7.4 at 25 °C and the therefrom ...
The SN1 reaction mechanism is a multi-step process that begins with the formation of the carbocation via the elimination of the leaving group. The nucleophile then attacks the carbocation.
<p>To understand why fluorine is the most reactive halogen, we can break down the explanation into several key points:</p><p>1. <strong>Identify the Halogens</strong>: - The halogens include fluorine (F), chlorine (Cl), bromine (Br), iodine (I), and a
In CGI-58, Asn155 replaces the putative active site nucleophile. A large, primarily helical lid region (Pro180–Leu280) is inserted after strand β6 and covers the potential “active site.” An additional feature of the model is a long partly helical, partly unstructured region ranging from...
Note: The laboratory synthesis of isopentyl diphosphate, the building block of the molecule used for constructing isoprenoid molecules such as cholesterol, etc was accomplished by conversion of alcohol to organic tosylate, and then displacing the tosylate group with inorganic pyrophosphate nucleophile...
Why can't an electrophile react with a nucleophile to form an ionic bond after all in some electrophile-nucleophile reactions ions are involved? In chemistry, what is a formula used to represent? How many paired electrons are there in Boron?