i.e. showed lower values for HER2-negative BC than for HER2-positive BC, p=0.041 for min values. For the remaining comparisons the p-values were not statistically significant; however, the analysis detected reasonable numerical tendency toward higher values in HER2-positive BC as compared to ...
strategies for patients with human epidermal growth factor receptor 2 (HER2)-positive disease and triple-negative breast cancer (TNBC) who have residual disease after preoperative systemic therapy.#There has been a shift towards neoadjuvant systemic therapy for selected patients with HER2-positive and ...
Approximately one in five breast cancers are driven by amplification and overexpression of the human epidermal growth factor receptor 2 (HER2) receptor kinase, and HER2-enriched (HER2E) is one of four major transcriptional subtypes of breast cancer. We s
Data reported at SABCS 2020 suggested that high Ki-67 levels in conjunction with high-risk features could be used to select patients who would benefit from the addition of abemaciclib (Verzenio) to endocrine therapy (ET) in the adjuvant treatment of ER-positive, HER2- negative stage I or II ...
Abstract P5-08-25: CKAP2 (cytoskeleton associated protein 2) is a new prognostic marker in HER2-negative luminal breast cancerBackground: Ki-67 has been increasingly used as a prognostic marker in spite of debates on the evaluation ... SH Sim,CD Bae,Y Kwon,... - 《Cancer Research》 被...
6b). Interestingly, the highest efficacy was achieved with abemaciclib (IC50 467 nM), a Cdk4/Cdk6 inhibitor, which was approved by the FDA in 2017 for the treatment of hormone receptor positive (HR+) and HER2-negative metastatic breast cancer40,41,42. Also, GSK1059615 (IC50 1079 nM...
negative (n = 160) 1.1 (1.0–1.2) 1.0 (0.6–1.8) 1.0 (0.97–1.0) 0.5 (0.3–1.0) 0.045 0.96 0.43 0.066 HER2 enriched if ER and PR negative and HER2 positive; Basal-like if negative for all ER, PR, and HER2 but expressing EGFR and/or CK5/6; and as Triple-negative non-basal if...
What is triple negative breast cancer? Triple negative breast cancer (TNBC) means that the cancer cells do not have estrogen (ER) and progesterone (PR) on their surface, and they do not over-express the HER2 protein as well (HER2−). In contrast to TNBC, triple positive breast cancer ...
(negative or very weak), 1 (weak), 2 (moderate), and 3 (strong). Score <1 was considered as negative, and score ≥1 as positive. Expression levels in each sample were calculated by summating the percentage of area stained at each intensity multiplied by the scored intensity (e.g., ...
Parsley is a good dietary source of apigenin, which has been shown to exhibit potent growth-inhibitory effects inHER2+breast cancer cells. Apigenin has also been shown to inhibit the growth of patient-derived triple negative (ER-/PR-/HER2-) organoids and sensitize triple negative cells toAdriam...