Triple positive: ER, PR and HER2 positive breast cancer Triple negative (basal like): HR and HER2 negative breast cancer What are the stages of breast cancer? Breast cancer is staged by the size of the tumor and extent of spread. Breast cancers are also graded from one to three, based ...
来源期刊 The Breast 研究点推荐 Luminal B/HER2-negative-like subtype 0关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术服务。在这里我们保持学习的态度,不忘初心,砥砺前行。了解更多>> 友情链接 ...
Luminal B/HER2-negative-like subtype is a predictor for local recurrence after breast-conserving surgery and shows no interaction with randomizationdoi:10.1016/s0960-9776(17)30340-5Wickberg, ?.Magnuson, A.Holmberg, L.Liljegren, G.The Breast...
Is it worth it to keep thrashing your legs and waving your arms and calling for help, or would it be better to fall under the water so everyone on the shore can waste no more time and get back to doing something more productive. A bit long-winded, but I suspect you get the point....
Additionally, cancers are highly diverse, and transcriptional profiling can often omit important aspects in the desire to pro- vide simple, distinct subtypes. These emphasize the need to better understand the underlying drivers and biology of HER2-amplified (HER2A) and HER2E breast tumors. We ...
Human epidermal growth factor receptor 2 (HER2) positive breast cancer accounts for 20–25% of all breast cancers. Multiple HER2-targeted therapies have been developed over the last few years, including the tyrosine kinase inhibitors (TKI) lapatinib, neratinib, tucatinib, and pyrotinib. These drug...
A significant proportion of breast cancers are driven by ErbB2/Her2 oncoprotein that they overexpress. These malignancies are typically treated with various ErbB2-targeted drugs, but many such cancers develop resistance to these agents and become incurab
“By using this profiling, I can tell you that you’re better with this one [drug] than this one. It’s going to make us smarter. So in this confusing world of oncology, where we have multiple choices and lines of therapy, my hope is that this AI technology will in fact make us ...
It is often presumed that these linkers are cleaved only after internalisation by the target cell with subsequent lysosomal degradation releasing free drug. ADCs with these linkers and appropriate drugs can kill not only the antigen-positive target cells but also the surrounding antigen-negative cells...
Parsley is a good dietary source of apigenin, which has been shown to exhibit potent growth-inhibitory effects in HER2+ breast cancer cells. Apigenin has also been shown to inhibit the growth of patient-derived triple negative (ER-/PR-/HER2-) organoids and sensitize triple negative cells to ...