This prospective cohort study tested whether the most common hereditary thrombophilia, factor V Leiden (FVL) mutation, is associated with nonpregnancy after IVF. Factor V Leiden mutation prevalence was very low (1.6%) and had a preliminarily positive association with pregnancy, suggesting that routine...
Further, homozygous polymorphic TT genotype for the MTHFR C677T polymorphism is the only hereditary risk factor that has been identified to be associated with increased blood pressure [8]. Although, there are many studies in the literature that investigated the association between variants of MTHFR ...
Prothrombotic states that predispose to stroke Hereditary prothrombotic states of clinical importance include factor V Leiden, the prothrombin 20210A mutation, deficienciesof protein C, protein S, or an... HSR Lentz - 《Current Treatment Options in Neurology》 被引量: 30发表: 2002年 加载更多来源...
Hereditary thrombophilia is responsible for approximately 40% of all thrombotic events. Case Report: Factor v Leiden mutation is the most common hereditary disorder in patients with venous thromboembolism. Other genetic disorders seen more common are prothrombin G20210A mutation, protein C deficiency, ...
In this case, protein S was the hereditary thrombophilic factor which has amplified the risk of thrombosis. Figure 1: Photomicrograph of bone marrow biopsy showing hyper- cellular marrow with megakaryocytic hyperplasia and hyperlobu- lated forms (400x). 2. Case Presentation 2.1. Case 1. A 40...
PS is a single-chain, 635–amino acid glycoprotein composed of an N-terminal domain rich in γ-carboxyglutamic acid (Gla domain; amino acids 1-45), a thrombin-sensitive region (TSR; amino acids 46-74), 4 epidermal growth factor (EGF)–like domains (amino acids 75-242), 9 and a larg...
Fourteen of 56 patients (25%) had a hereditary thrombophilia, mostly factor V Leiden. Patients with both CVT and hereditary thrombophilia had more frequently a positive family and personal history than patients affected by CVT only but the difference was not strong enough to differ from the 42 ...
The factor V Leiden mutation may predispose women to severe preeclampsia. Am J Obstet Gynecol 1996;175:902– 905. 49. Moor E, Silveira A, van't Hooft F et al. Coagulation factor VII mass and activity in young men with myocardial infarction at a young age: Role of plasma lipoproteins ...
Effect of second-and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial. Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test. Thromb Haemost. ...
(Oxygraph Plus; Hansatech Instruments, Norfolk, United Kingdom). The electrode was equilibrated to 100% O2saturation by bubbling O2through the buffer and for 0% saturation by bubbling with N2until the respective plateaus were reached to derive an offset and a calibration factor. Experiments were ...