The risk of recurrent venous thromboembolism in heterozygous carriers of factor V Leiden and a first spontaneous venous thromboembolism. Factor V (FV) Leiden is a risk factor for venous thrombosis (VT). Data on its influence on the risk of recurrent venous thromboembolism (VTE) are controver.....
Inherited factors have been shown to be important in the pathogenesis of varicose veins [1], but a detailed analysis of genetic factors in patients with leg ulcers has not been published. Recently an association has been shown between factor V Leiden gene defect and venous ulceration [2]. ...
For example, carriership of the Factor V Leiden (FVL) mutation increases the risk for venous thromboembo- lism (VTE) to an estimated 10–20% in a lifetime, but the genotype is neither sufficient nor necessary for VTE to occur.42 Genetic components of multifactorial traits can affect the ...
The factor V Leiden mutation may predispose women to severe preeclampsia. Am J Obstet Gynecol 1996;175:902– 905. 49. Moor E, Silveira A, van't Hooft F et al. Coagulation factor VII mass and activity in young men with myocardial infarction at a young age: Role of plasma lipoproteins ...
Results: Compared with controls, placental abruption was more often associated with homozygous and heterozygous factor V Leiden mutation, heterozygous G20210A prothrombin gene mutation, homocysteinaemia, activated protein C resistance or anticardiolipin IgG antibodies. Women with pre-eclampsia/eclampsia were...
In all cases, a naive helper T cell precursor (P) activated in the presence of the Th2-promoting factor, IL-4, proliferates and ultimately gives rise to a predominant population of Th2 (blue) cells. The bold arrows indicate at which cellular stage IL-4 is acting. Instructive models pred...
The development of efficient and safe vectors for gene delivery paved the way for evolution of gene therapy as a new modality for treatment of various inherited disorders and for cancer. The current vectors, viral and non-viral, have their limitations. I
View further author informationhttps://orcid.org/0000-0001-8795-156Xe.m.michaels@fgga.leidenuniv.nlEva Michaels
Volume 79, Number 4 | Factor V Leiden: How great is the risk of venous thromboembolism?VolumeCleveland Clinic Journal of Medicine