(redirected fromFactor V Leiden mutation) Thesaurus Medical Legal Acronyms Encyclopedia mu·ta·tion (myo͞o-tā′shən) n. 1.The act or process of being altered or changed. 2.An alteration or change, as in nature, form, or quality. ...
This article will review the factor V Leiden mutation, its association with VTE, and the genetic inheritance pattern and ethnic distribution. Oral contraceptive use, pregnancy, and hormone replacement therapy in women with the Leiden mutation will be discussed. Screening issues and management for all...
prevalence of 50% (4 of 8 patients) and a relative risk of venous thrombosis in IBD patients with factor V Leiden of 23 (95% confidence interval, 2-294; P = 0.005).In patients with IBD, inheritance of the factor V Leiden mutation results in a significant increased risk of venous ...
another a crossing-over event were ,*most likely explanations for the observed inheritance patterns.In six families with type I or II antithrombin deficiency (reactive sitepleiotropic effect), 11 of the 12 individuals with both antithrombin ..iiciency and the factor V mutation developed thrombosis....
Define Factor VII deficiency. Factor VII deficiency synonyms, Factor VII deficiency pronunciation, Factor VII deficiency translation, English dictionary definition of Factor VII deficiency. Noun 1. factor VII - a coagulation factor formed in the kidney u
Testing The diagnosis of Factor V Leiden requires the APC resis- tance assay, a coagulation screening test, or DNA analysis of F5, the gene encoding Factor V, to identify the Leiden mutation, a specific G-to-A substitution at nucleotide 1691 that predicts a single-amino acid replacement (R...
Factor V Leiden mutation as a risk factor for recurrent pregnancy loss. BACKGROUND: Recurrent pregnancy loss may result from hypercoagulability. OBJECTIVE: To determine whether women with factor V Leiden mutation, a common inhe... Ridker,M Paul - 《Annals of Internal Medicine》 被引量: 398发...
Approximately 10% of mutation carriers experience clinically significant thrombosis in their lifetime. In a small subset of patients, thrombosis is associated with coinheritance of other prothrombotic gene mutations. However, the potential contribution of additional genetic risk factors in the majority of...
to distinguish heterozygotes from homozygotes. Patients on heparin therapy or with known lupus anticoagulant should proceed directly to molecular testing if the modified functional assay is not used. When relatives of individuals known to have factor V Leiden are tested, the DNA method is recommended...
Factor V Leiden causing activated protein C resistance is the most common inherited form of thrombophilia leading to thrombosis. Its frequency shows great ethnic and geographic variations. The aim of this study was to determine the frequency of FV Leiden and coinheritance of FV Leiden with two oth...