Factor V Leiden mutation is a common genetic risk factor for venous thrombosis. It has been documented in up to 65% of patients with unexplained venous thromboembolism. This genetic mutation is now known to be the most common inherited cause of activated protein C (APC) resistance. Recently, ...
The meaning of FACTOR V LEIDEN is a point mutation producing an abnormal version of factor V that is resistant to inactivation and causes prolonged clotting of blood.
We investigated the presence of the gene mutation of factor V, FV ^l)6Q or factor V Leiden, responsible for activated protein C resis- nce, in DNA samples of 127 probands and 188 relatives from 128 jinhes with antithrombin deficiency.The factor V mutationwas iden- ned in 18 families. Ni...
Molecular Testing for Factor V Leiden and Prothrombin Gene Mutations in Inherited ThrombophiliaFactor IIFactor V LeidenFVLProthrombinThrombophiliaWe report an 81-year-old female with a heterozygous factor V Leiden mutation who developed purpura fulminans. Digital necrosis, a characteristic clinical feature ...
Factor V LeidenthrombosismutationprothrombinNormal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. Inherited alteration of factor V and prothrombin gene, the G20210A mutation, increases the resistance of factor V to degradation and booster production of prothrombin ...
FACTOR-V LEIDEN: A RISK FACTOR FOR CEREBRAL PALSY 来自 Semantic Scholar 喜欢 0 阅读量: 13 作者:K Harum,A Hoon,J Casella 摘要: Inherited and acquired thrombophilic disorders have recently been associated with cerebral palsy (CP) and complications in pregnancy. Thrombophilic disorders are not ...
screening, or individuals taking an oral contraceptive [2]. A negative result of this test does not rule out inherited thrombophilia. Other than factor V Leiden, variants in the genes that encode coagulation factor II, protein C, protein S, and antithrombin can also cause inherited thrombophilia...
The factor V Leiden (FVL) mutation is the most common cause of inherited thrombophilia in Caucasian populations, and women with this variant allele are at increased risk for pregnancy complications. To examine whether the FVL allele is associated with pregnancy complications and adverse outcomes in ...
Our results emphasize the impact of factor V Leiden on thrombogenesis in children. However, the significance is age-dependent and may reflect the different physiology of haemostasis in the three age groups. The diagnostic workup of children with thrombosis should inelude tests for factor V Leiden...
18 APC resistance, caused by a mutation in factor V (factor V Leiden), which renders factor Va unable to be cleaved by APC, is by far the most common inherited defect associated with venous thrombosis. This mechanism and the related role of thrombin activation and protein C are summarized ...