Inheritance of Factor V Leiden has severe consequences. Clinical case of a patient with multiple episodes of venous thrombosis and dramatic development.Buryan KirovBoris SakakusevPetr SlavovDonco Kotasov
Twitter Google Share on Facebook (redirected fromFactor V Leiden mutation) Thesaurus Medical Legal Acronyms Encyclopedia mu·ta·tion (myo͞o-tā′shən) n. 1.The act or process of being altered or changed. 2.An alteration or change, as in nature, form, or quality. ...
another a crossing-over event were ,*most likely explanations for the observed inheritance patterns.In six families with type I or II antithrombin deficiency (reactive sitepleiotropic effect), 11 of the 12 individuals with both antithrombin ..iiciency and the factor V mutation developed thrombosis....
Define Factor VII deficiency. Factor VII deficiency synonyms, Factor VII deficiency pronunciation, Factor VII deficiency translation, English dictionary definition of Factor VII deficiency. Noun 1. factor VII - a coagulation factor formed in the kidney u
prevalence of 50% (4 of 8 patients) and a relative risk of venous thrombosis in IBD patients with factor V Leiden of 23 (95% confidence interval, 2-294; P = 0.005).In patients with IBD, inheritance of the factor V Leiden mutation results in a significant increased risk of venous ...
The molecular basis of type I or III Protein S deficiency has been investigated in three kindred also showing independent inheritance of factor V (FV) Leiden. A T to C transition in codon 570 (Met → Thr) was identified in the propositi and shown to segregate with protein S deficiency in...
Therefore, the inheritance of thrombophilia-related genes may be an important factor in the pathophysiology of recurrent pregnancy loss. Most of the research on recurrent pregnancy loss and thrombophilia has focused on maternal factors, but little is known about the paternal contribution. ObjectivesOn ...
Coinheritance of a Factor V null allele occurs in approximately 1:1000 individuals heterozygous for Factor V Leiden. Rather than attenuating the effect of a Factor V Leiden allele, a coexisting Factor V deficiency enhances it, producing a more severe APC-resistant phenotype, reflected by an ...
Factor V deficiency can be either inherited or acquired. The 2 forms arise from different causes, explained below. Inherited Factor V Deficiency Inheritance of the condition follows an autosomal recessive pattern, with F5 gene (1q23) mutations being transmitted either homozygously or heterozygously....
Factor V Leiden causing activated protein C resistance is the most common inherited form of thrombophilia leading to thrombosis. Its frequency shows great ethnic and geographic variations. The aim of this study was to determine the frequency of FV Leiden and coinheritance of FV Leiden with two oth...