Factor V Leiden is the most common known hereditary abnormality of the clotting system which leads to a reduced anticoagulant effect of activated protein C (APC resistance). FactorV Leiden has been shown to be the most frequent inherited thrombophilic disorder in patients with idiopathic venous ...
Inherited thrombophilia.This means you were born with the condition. One or both of your parents passed on a faulty gene or genes. Inherited thrombophilia comes in several forms. The most common arefactor V Leidenmutation, which 1 in 20 people of European descent have, and the prothrombin G20...
Genetic risk factors of thrombosis in the antiphospholipid syndrome. Br J Haematol. 2009;147:289–96. Article PubMed CAS Google Scholar Simantov R, Lo SK, Salmon JE, Sammaritano LR, Silverstein RL. Factor V Leiden increases the risk of thrombosis in patients with antiphospholipid antibodies. ...
I Beydilli,N Kozaci,F Gungor,A Ari 摘要: Introduction: Thrombophilia is a hemostatic disorder that defined as a tendency to thrombosis. It can be hereditary and acquired. Hereditary thrombophilia is responsible for approximately 40% of all thrombotic events. Case Report: Factor v Leiden mutation...
Taken together, we do not think that altered APP expression in EC-DCN is a contributing factor to the differences in pathology. In addition, we also examined a selection of genes directly involved in APP processing and generation of Aβ [98,99,100,101]. In our dataset, the expression of...
Example 1 Table Analysis of Oral Contraceptive Use, Presence of Factor V Leiden Allele, and Risk for Venous Thromboembolism Example 2 Table Sensitivity of the Rate Ratio for Cardiovascular Outcome to an Unmeasured Confounder Explanation In addition to the main analysis other analyses are often done ...
Effect of second-and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial. Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test. Thromb Haemost. ...
The sentinel SNP of the third identified locus (rs1736891, MAF = 0.38) was associated with the expression of several nearby genes annotated as zinc fingers (Supplementary Data8), but most strongly with downregulation of the expression of the nearby transcription factor35ZSCAN9gene located on...
32 Chu CH, Liu CJ, Fuh JL, Shiao AS, Chen TJ, Wang SJ: Migraine is a risk factor for sudden sensorineural hearing loss: a nationwide population-based study. Cephalalgia 2013; 33: 80–86. 33 Cha YH, Kane MJ, Baloh RW: Familial clustering of migraine, episodic vertigo, and Meniere's...
Relative quantification was performed using standard curves, followed by adjustment with the normalization factor calculated by geNorm program [25]. The average relative expression of gene of interest in ECs was compared to controls. To see the EC specific gene expression changes, relative expression ...