Factor V Leiden is the most common known hereditary abnormality of the clotting system which leads to a reduced anticoagulant effect of activated protein C (APC resistance). FactorV Leiden has been shown to be the most frequent inherited thrombophilic disorder in patients with idiopathic venous ...
Inherited thrombophilia.This means you were born with the condition. One or both of your parents passed on a faulty gene or genes. Inherited thrombophilia comes in several forms. The most common arefactor V Leidenmutation, which 1 in 20 people of European descent have, and the prothrombin G20...
I Beydilli,N Kozaci,F Gungor,A Ari 摘要: Introduction: Thrombophilia is a hemostatic disorder that defined as a tendency to thrombosis. It can be hereditary and acquired. Hereditary thrombophilia is responsible for approximately 40% of all thrombotic events. Case Report: Factor v Leiden mutation...
Example 1 Table Analysis of Oral Contraceptive Use, Presence of Factor V Leiden Allele, and Risk for Venous Thromboembolism Example 2 Table Sensitivity of the Rate Ratio for Cardiovascular Outcome to an Unmeasured Confounder Explanation In addition to the main analysis other analyses are often done ...
32 Chu CH, Liu CJ, Fuh JL, Shiao AS, Chen TJ, Wang SJ: Migraine is a risk factor for sudden sensorineural hearing loss: a nationwide population-based study. Cephalalgia 2013; 33: 80–86. 33 Cha YH, Kane MJ, Baloh RW: Familial clustering of migraine, episodic vertigo, and Meniere's...
The sentinel SNP of the third identified locus (rs1736891, MAF = 0.38) was associated with the expression of several nearby genes annotated as zinc fingers (Supplementary Data8), but most strongly with downregulation of the expression of the nearby transcription factor35ZSCAN9gene located on...
(Phosphoinositide-3-Kinase Regulatory Subunit 1; degree = 18), a major astrocytic hub gene and a subunit of PI3K that has been identified as a novel genetic variant in the progression of AD [46]. While the implications of the enrichment of insulin and PI3K–AKT/Rho GTPase signalling ...
Relative quantification was performed using standard curves, followed by adjustment with the normalization factor calculated by geNorm program [25]. The average relative expression of gene of interest in ECs was compared to controls. To see the EC specific gene expression changes, relative expression ...
Chronic complex I inhibition has clearly been shown to lead to dopaminergic neuron death and α-synuclein accumulation (12, 13, 14, 15, 16) and is a major factor implicating mitochondrial dysfunction in sporadic Parkinson's disease. Chronic complex I inhibition can impact mitochondrial fitness and...
factor (BDNF) and tropomyosin receptor kinase B/neurotrophic tyrosine kinase receptor type 2 (TrkB/NTRK2) as possible genetic factors.11 The latter two are part of a cerebral signaling pathway, which is essential for the regulation of neuronal gene transcription, neurogenesis, and 1Institute of ...