A. hemoglobin B. CFTR C. sickle cell D. red blood cell 相关知识点: 试题来源: 解析 B。解析:文章中明确提到 Cystic fibrosis is caused by mutations in a gene that codes for a protein called the cystic fibrosis transmembrane conductance regulator (CFTR).。反馈...
CFTR, the cystic fibrosis (CF) gene, encodes for the CFTR protein that plays an essential role in anion regulation and tissue homeostasis of various epithelia. In the gastrointestinal (GI) tract CFTR promotes chloride and bicarbonate secretion, playing an essential role in ion and acid-base ...
CFTR, the cystic fibrosis (CF) gene, encodes for the CFTR protein that plays an essential role in anion regulation and tissue homeostasis of various epithelia. In the gastrointestinal (GI) tract CFTR promotes chloride and bicarbonate secretion, playing an essential role in ion and acid–base home...
When Klotho was missing, the modification of YAP protein phosphorylation by AMPK was blocked, leading to the activation of the YAP/TAZ signal transduction pathway and ultimately causing the overgrowth of vascular endothelial cells. Posted in Cftr Pathway | Leave a reply Morphometric and conventional...
Cystic fibrosis(CF) is an autosomal recessive disorder caused by a mutation in the CFTR gene, which encodes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Variations of the mutation, such as lack of synthesis, misfolding, or abnormal trafficking to the cell membrane wi...
While CFTR is expressed along the entire nephron, its function in renal tubule epithelial cells remains unclear, as no specific renal phenotype has been identified in cystic fibrosis. CFTR has been proposed as a regulator of the 30 pS, ATP-sensitive renal K channel (Kir1.1, also known as ...
In conclusion, our data suggest that 621+3 A4G should not be considered a severe CF mutation because of its frequency in the population, because it still allows the synthesis of significant amounts of functional CFTR protein, and the absence of clinical disease in a compound (621+3 A4G/ Q5...
Transient expression of wild-type CFTR in the presence of submicromolar concentrations of MG-132 blocks maturation of the protein. We found that expression of CFTR in the presence of MG-132 trapped the protein in a trypsin-sensitive conformation. In addition, the structure of the carboxyl-...
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Cystic fibrosis (CF) is an autosomal recessive inherited disorder in which absence or dysfunction of an epithelial sodium channel, the CFTR (CF transmembrane conductance regulator protein), leads to thick secretions and multisystem complications, including suppurative lung disease, sinus disease, pancreatic...