CFTR, the cystic fibrosis (CF) gene, encodes for the CFTR protein that plays an essential role in anion regulation and tissue homeostasis of various epithelia. In the gastrointestinal (GI) tract CFTR promotes chloride and bicarbonate secretion, playing an essential role in ion and acid-base ...
CFTR, the cystic fibrosis (CF) gene, encodes for the CFTR protein that plays an essential role in anion regulation and tissue homeostasis of various epithelia. In the gastrointestinal (GI) tract CFTR promotes chloride and bicarbonate secretion, playing an essential role in ion and acid–base home...
When Klotho was missing, the modification of YAP protein phosphorylation by AMPK was blocked, leading to the activation of the YAP/TAZ signal transduction pathway and ultimately causing the overgrowth of vascular endothelial cells. Posted in Cftr Pathway | Leave a reply Morphometric and conventional...
Cystic fibrosis is caused by a gene called CFTR. A. 相关知识点: 试题来源: 解析 B [概括大意] 见第三段第一句,“Cystic fibrosis is caused by defects in a gene called CFTR.”囊性纤维变性是由一种叫做CFTR的基因的缺陷所造成的。反馈 收藏 ...
Cystic fibrosis(CF) is an autosomal recessive disorder caused by a mutation in the CFTR gene, which encodes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Variations of the mutation, such as lack of synthesis, misfolding, or abnormal trafficking to the cell membrane wi...
Cystic fibrosis (CF) is an autosomal recessive inherited disorder in which absence or dysfunction of an epithelial sodium channel, the CFTR (CF transmembrane conductance regulator protein), leads to thick secretions and multisystem complications, including suppurative lung disease, sinus disease, pancreatic...
M. Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues. Nat. Med. 7, 493–496 (2001). Article CAS PubMed Google Scholar Sun, C. et al. Spatially resolved metabolomics to discover tumor-associated metabolic alterations. Proc. Natl Acad. ...
People with CFinheritedtwo copies of a defective or mutated CF gene, meaning each parent was a carrier for CF. Called the cystic fibrosis transmembrane conductance regulator (CFTR) gene, this mutation prevents the CFTR protein from working properly. ...
Thyroxine treatment had no effect on the expression of AT1R, AT2R, or MasR expression (Fig. 6) in renal membrane fractions. Fig. 6 The effect of thyroxine treatment on the expression of AT1R, AT2R and MasR proteins in renal membranes. (A) Representative Western blot of AT1R protein expre...
In conclusion, our data suggest that 621+3 A4G should not be considered a severe CF mutation because of its frequency in the population, because it still allows the synthesis of significant amounts of functional CFTR protein, and the absence of clinical disease in a compound (621+3 A4G/ Q5...