Glia is no longer glue: A new dawn of a decade of astrocytesNo abstract is available for this article.doi:10.1111/cen3.12044Akio SuzumuraJohn Wiley & Sons, LtdClinical and Experimental Neuroimmunology
A key role for astrocytes in synapse formation and function has been proposed. Here, we show that transforming growth factor β (TGF-β) signaling is a novel synaptogenic pathway for cortical neurons induced by murine and human astrocytes. By combining gain and loss of function approaches, we ...
Astrocytes play crucial roles in regulating neural circuit function by forming a dense network of synapseassociated membrane specializations, but signaling pathways regulating astrocyte morphogenesis remain poorly defined. Here, we show the Drosophila lipid -binding G protein -coupled receptor (GPCR) Tre1...
Astrocytes establish rapid cell-to-cell communication through the release of chemical transmitters. The underlying mechanisms and functional significance of this release are, however, not well understood. Here we identify an astrocytic vesicular compartment that is competent for glutamate exocytosis. Using ...
Single-nucleus RNA-sequencing revealed that the removal of neuronal APOE4 greatly diminished neurodegenerative disease-associated subpopulations of neurons, oligodendrocytes, astrocytes and microglia whose accumulation correlated to the severity of tau pathology, neurodegeneration and myelin deficits. Thus, ...
While histidine uptake was more active into synaptosomes than into astrocytes, only astrocytes were capable of a significant HA uptake. Kinetic analysis of the astrocytic HA uptake revealed a high affinity-low capacity system ( K m = 5·10 −7 M, V max = 1.6·10 −12 mol·min −1...
doi:10.1002/glia.22844GLT-1, GLAST, EAAT1, EAAT2, postnatal development, membrane resistance, developmental plasticity, glial developmentGlutamate uptake by astrocytes controls the time course of glutamate in the extracellular space and affects neurotransmission, synaptogenesis, and circuit development. ...
Astrocytes were selectively labeled, but showed greatly varying labeling intensities. This astroglial heterogeneity resulted in an astrocyte domain‐like labeling pattern. Strong xCT labeling was also found in the leptomeninges, along some blood vessels, in selected circumventricular organs and in a ...
A single-cell transcriptomic dataset of pluripotent stem cell-derived astrocytes via NFIB/SOX9 overexpression Article Open access 10 September 2024 Human iPSC-derived neural stem cells displaying radial glia signature exhibit long-term safety in mice Article Open access 01 November 2024 Data availa...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by glia over-proliferation, neuro-inflammation, perturbed neural circuitry, and gastrointestinal symptoms. The role of gut dys-biosis in ASD is intriguing and should be elucidated. We investigated the effect of Propionic acid ...