Thus far, little is known about the profiles of iron deposition in different liver zones, particularly under conditions with disordered iron homeostasis. Here, uneven iron distribution in livers of patients with hereditary hemochromatosis (HH) is uncovered, showing the region with the highest iron ...
Iron deposition in the liver and guts of giant South American freshwater turtle Podocnemis expansa (Schweigger 1812) from a commercial breeding farm in Acr... A Conrado,AD Oliveira,L Medeiros,... - 《Multidisciplinary Science Journal》 被引量: 0发表: 2022年 Avaliação da cavidade oro...
iron is bound to the iron–sulfur cluster, and binding to IRPs can prevent IRP-IRE interactions. At the whole-body level, iron regulation is mainly dependent on hepcidin, a liver-derived sex steroid hormone that is an important regulator of iron homeostasis [34]. Hepcidin binds to...
iron is bound to the iron–sulfur cluster, and binding to IRPs can prevent IRP-IRE interactions. At the whole-body level, iron regulation is mainly dependent on hepcidin, a liver-derived sex steroid hormone that is an important regulator of iron homeostasis [34]. Hepcidin binds to...
Perls' staining showed an iron staining pattern that is predominantly hepatocellular and periportal in location in the Hfe À / À mice, but those fed chow or HFD with ethanol also displayed some reticuloendothelial iron deposition (Figure 1b). Iron staining was not evident in any of the ...
However, before a course of treatment was established, the patient's clinical condition worsened, and chelation therapy was no longer feasible. He was referred for combined heart and liver transplantation. Cardiac iron deposition can be diagnosed readily using right ventricular biopsy or T2* magnetic...
Identification of human liver carboxylesterase as a specific protein bound to Plasmodium falciparum malaria sporozoties and the association with sporozotie invasion in cultured human hepatocytes Hepatology, Volume 22, Issue 4, Part 2, October 1995, Pages A290 PDF (163 K) Justification of a single ...
The initial biopsies obtained prior to or within 21 months after beginning chelation therapy had Grade IV iron staining, with heavy iron deposition present in parenchymal and reticuloendothelial cells. Subsequent biopsies, obtained when serum ferritin levels had fallen to 71-246 μg/1, contained ...
Alcohol-induced increase in hepatic transferrin receptor-1 expression and up-regulation of high iron protein in Kupffer cells (proposed) facilitate iron deposition and retention in the liver. Iron is loaded in both parenchymal and nonparenchymal liver cells. Iron-loaded liver can promote ferroptosis ...
Liver fibrosis can be classified as a wound healing response to a variety of chronic stimuli that is characterized by an excessive deposition of extracellular matrix (ECM)...Harada Y, Iwai M, Kakusui M, et al. Activated hepatic stellate cells participate in liver fibrosis in a patient with ...