iron - liver - human - animalIron deposition occurs in parenchymal cells of the liver in two major defects in human subjects (i) in primary iron overload (genetic haemochromatosis) and (ii) secondary to anaemias in which erythropolesis is increased (thalassaemia). Transfusional iron overload...
Iron deposition in the liver and guts of giant South American freshwater turtle Podocnemis expansa (Schweigger 1812) from a commercial breeding farm in Acr... A Conrado,AD Oliveira,L Medeiros,... - 《Multidisciplinary Science Journal》 被引量: 0发表: 2022年 Avaliação da cavidade oro...
Hereditary hemochromatosis (HH) is a disease of iron overload leading to the accumulation of iron in specific organs including the liver, heart, pancreas and gonads. From:The International Journal of Biochemistry & Cell Biology,2001 About this page ...
Iron overload leads to an increase in ROS production, which not only damages cell components, but also serves as a potential basis for the development of diseases [151]. Many studies have shown that antioxidants can reduce heart oxidative stress, reduce heart iron deposition, and improve heart ...
(NCOA4), is used to mobilize the stored iron from the liver [26,30]. The physiological range of liver iron deposition is 300 mg to 1 g, but it can reach as high as 25 to 30 g in patients with hereditary hemochromatosis [31]. When the level of serum iron is at about 60% ...
Alcohol-induced increase in hepatic transferrin receptor-1 expression and up-regulation of high iron protein in Kupffer cells (proposed) facilitate iron deposition and retention in the liver. Iron is loaded in both parenchymal and nonparenchymal liver cells. Iron-loaded liver can promote ferroptosis ...
Non-alcoholic fatty liver disease (NAFLD) is a common cause of elevated liver function tests and is marked histologically by deposition of fat, primarily macrovesicular, in hepatocytes. Although a benign disorder in the majority of instances, up to 20% of patients with NAFLD have nonalcoholic st...
Lesley A Jaskowski1,2, V Nathan Subramaniam1,2,4, Andrew D Clouston1, Denis I Crane5, Kim R Bridle1,2, Gregory J Anderson4 and Linda M Fletcher1,3 Endoplasmic reticulum (ER) stress is an important pathogenic mechanism for alcoholic (ALD) and nonalcoholic fatty liver disease (NAFLD)....
Pattern of Iron Deposition in Hepatic Cells in ALD There are two different proposals with regard to iron deposition in the different cell types of the liver. According to one proposal, in mild ALD, iron is preferably deposited in the hepatocytes (parenchymal cells of the liver). As the condit...
Hepatic iron overload in alcoholic end-stage liver disease is associated with iron deposition in other organs in the absence of HFE-1 hemochromatosis. Liver International, 2005, 25(3): 513-517. [8] D. Lin, et al. Decreased Serum Hepcidin Concentration Correlates with Brain Iron Deposition in...